Bioactive Compounds from Hot Spring and Volcanic Microorganisms

Q3 Multidisciplinary Philippine Journal of Science Pub Date : 2023-03-07 DOI:10.56899/152.03.01
Fleurdeliz Maglangit, K. Miranda, Mariel Rose Villarubia, D. Dalman
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引用次数: 0

Abstract

Antimicrobial resistance (AMR) is a threatening global health challenge with an estimated annual death toll of 10 million by 2050 if unabated. Therefore, there is a mounting urgency to find new sources of clinical candidates for the development of drugs that are effective against drug-resistant infections and cancer. Hot springs and volcanic environments represent valuable sources of novel natural products (NPs) – including polyketides, alkaloids, and peptides – yet largely untapped and understudied. Microbes from these niches have been found to develop unique defenses to thrive in extreme temperatures and harsh conditions, leading to the biosynthesis of novel molecules with unique chemical architectures and remarkable biological activities. The present review surveys the bioactive NPs from hot springs and volcanic microbes from 2006–2022, highlighting their chemical structures and biological potential. Notably, the compounds ohmyungsamycin A, dicitrinone B, and terrein displayed more potent cytotoxic effects on several cancer cell lines compared to the current chemotherapy drugs, indicating a promising potential for drug development. The continued exploration of extreme microbes will undoubtedly bring many discoveries of bioactive molecules potentially valuable for biotechnological or pharmaceutical applications.
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温泉和火山微生物的生物活性化合物
抗菌素耐药性(AMR)是一项威胁全球健康的挑战,如果不减少,到2050年估计每年死亡人数将达到1000万。因此,迫切需要寻找新的临床候选药物来源,以开发有效对抗耐药感染和癌症的药物。温泉和火山环境是新型天然产物(NPs)的宝贵来源,包括聚酮、生物碱和肽,但大部分尚未开发和研究不足。来自这些生态位的微生物已经被发现在极端温度和恶劣条件下发展出独特的防御能力,从而导致具有独特化学结构和显著生物活性的新分子的生物合成。本文综述了2006-2022年从温泉和火山微生物中提取的生物活性NPs,重点介绍了它们的化学结构和生物潜力。值得注意的是,与目前的化疗药物相比,这些化合物对几种癌细胞的细胞毒作用更强,这表明药物开发的潜力很大。对极端微生物的持续探索无疑会带来许多生物活性分子的发现,这些分子对生物技术或制药应用具有潜在的价值。
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来源期刊
Philippine Journal of Science
Philippine Journal of Science Multidisciplinary-Multidisciplinary
CiteScore
1.20
自引率
0.00%
发文量
55
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