Individualized endoscopic treatment for pregnant patients with acute pancreaticobiliary diseases

Abstract

Background: Acute pancreaticobiliary diseases are more prevalent and can often lead to severe maternal and fetal morbidity and mortality during pregnancy period. It is very important that early relieving biliary obstruction. Aims: To evaluate the safety and efficacy of individualized endoscopic treatment in managing acute pancreaticobiliary diseases in pregnant patients. Settings and Design: It is a single-center, retrospective study. Materials and Methods: Clinical data of 86 pregnant women with acute pancreaticobiliary diseases treated using individualized endoscopic treatment from January 2012 to January 2016 were analyzed retrospectively. The primary observed indicators included the operation success rate, recovery of laboratory indicators 1 week after the first endoscopic treatment, complications, prognosis, hospital stay, and different effect of individualized endoscopic therapy during different pregnancy period. Statistical Analysis Used: Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 13.0 statistical software. Descriptive statistics was used. Results: The operation success rate was 97.67% (84/86) in all patients. Postoperative abdominal pain, fever, and other clinical symptoms were improved rapidly in patients. The laboratory indicators 1 week after the first endoscopic treatment were improved significantly (P < 0.05). The complications included biliary bleeding, acute cholangitis, postendoscopic retrograde cholangiopancreatography pancreatitis, and hyperamylasemia in 2, 1, 2, and 2 cases, respectively. The complication rate was 8.14% (7/86). The mean hospital stay of patients was 16.02 ± 4.32 days. Moreover, there was not statistically significant difference in the effect of endoscopic therapy during different pregnancy period (P > 0.05). Conclusions: Due to the good safety, marked effect, and little complications, individualized endoscopic treatment should be preferred therapy for patients with acute pancreaticobiliary diseases during pregnancy when performed by experienced hands.