The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?

Q3 Medicine International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2022-10-01 DOI:10.18502/ijhoscr.v16i4.10883

Atousa Haghi, Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Reza Eghdami, Mohsen Nikbakht

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Abstract

Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed the dimensional role of autophagy in leukemia.

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生存或死亡的问题:自噬在急性髓性白血病(AML)中的作用是什么?

自噬在应对恶劣条件和营养剥夺时平衡能量来源方面起着关键作用。自噬可以使细胞在恶劣条件下存活，也可以作为一种死亡机制。自噬信号的任何失调都可能导致多种疾病。自噬被认为可以解释急性髓性白血病(AML)的化疗耐药。该信号通路可能具有抑制肿瘤的功能，也可能具有耐药机制。常规化疗药物可促进细胞凋亡，临床获益，但部分病例出现复发和化疗耐药。在白血病中，自噬可以促进细胞对化疗药物的存活。因此，通过抑制或激活自噬的新策略可能会在治疗白血病中找到广泛的应用，并可能显著提高临床效果。在这篇综述中，我们讨论了自噬在白血病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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