Early Surgical Correction of Ureteropelvic Junction Obstruction

Abstract

Based on the analysis of 131 (from month 1 to 3 years old) children with Ureteropelvic Junction (UPJ) obstruction, who underwent early pyeloplasty, it was found that the incidence of intra and postoperative complications in both groups remains identical. Good and satisfactory results obtained from Group I (91) in 89 (98%) patients, and from Group II (40) in 38 (95%) children proved high efficiency of surgical treatment and the expediency of early pyeloplasty. Based on this research, it may be concluded that, it is baseless to prolong children observation with congenital hydronephrosis, in order to prevent intraand postoperative complications associated with early children age. In turn, early correction of obstruction of UPJ, in the absence of infection, leads to the preservation of kidney function and creates optimal conditions and prerequisites for the development and growth of functional structures. Table 1: Characteristic of clinical manifestation was different in each age group. Groups Non-symptom Palpable Mass UTI Abdominal Pain Abs % Abs % Abs % Abs % Group 1 85 66 1 0,8 6 4,5 Group 2 29 22 1 0,8 5 3,5 2 1,6 All 114 88 2 1,6 11 8 2 1,6 Citation:Agzamkhodjaev ST, Abdullaev ZB, Sanginov ShA, Umargaliev SD. Early Surgical Correction of Ureteropelvic Junction Obstruction. J Urol Nephrol. 2018;5(1): 2. J Urol Nephrol 5(1): 2 (2018) Page 02 ISSN: 2380-0585 Where patients have improved renal function, in pelvic size with absent clinical manifesting during assessment period did not undergo surgical correction, and were excluded from this study. Dismembered pyeloplasty with modification was performed in all patients. Surgical approach carried out intramuscularly in lumbar area. During surgical correction, all patients had PUJ resection following morphological assessment. Resection of pelvic was performed only in cases of massive dilatation of collecting. Postoperatively, for 7-8 days, collecting system was drained with intubating pyelostomy. All patients received antibiotic therapy for 7 days after surgery. All patients followed checkup after 3, 6 month and 1, 3 years after surgical treatment. We performed lab tests and US scan to assess dynamics of collecting system dilatation, kidney improvement and parenchymal recover. Intravenous urography performed after 6 month of surgery to study morph-functional state of affected kidney and upper urinary tract. Assessment of differential function made after 1 year through diuretic renogram. All results of surgical PUJ correction depending on achieving or unchanged state of urodynamic recover divided in three categories: conditions evaluated as good, satisfactory and non-satisfactory results. Good results were evaluated as satisfactory when there were absence of pathologic changes in urine tests, clinic manifestation development as pain syndrome, improved collector segment size on US scan, urine excretory function recover and improvement in differential renal function. Satisfactory group characterized with transitional changes in urine tests, periodical clinic symptoms and complaints, slightly or practical unchanged collector system of kidney and excretory function. In non-satisfactory group noted pyelonephritis exacerbation, worsening dilatation of collecting system with damaged kidney blood supply, non-recovered evacuation of contrast media and differential renal function on diuretic renogram. Results and Discussion One hundred thirteen pyeloplasty procedures were performed in 92 infants in Group I (21 bilateral) and 42 procedures in 37 patients in Group II (5 bilateral). All surgeries went well without intraoperative complications. No case has held hemotransfusion intraand postoperatively. Despite fact that children were in small age and infant type body development, there was no obvious difference in results between I and II group. Clinical manifestation of urinary tract infection was observed in 4 (4%) and only 1 (2%) patient in group I and II respectively. In postoperative period of Group I, 4 patients had a complication, which is corresponded to grade I in P. Clavien’s classification. In comparision, group II had slightly lower complication rate (2%), however it did not reach statistical significance. In addition, performed pyeloplasty on infants in first group did not affected patient`s hospital stay (mean 5+2 days). If good and satisfactory results were achieved in 89 of 92 (97%) patients of Group I, the same results were in Group II as 35 of 37 (95%). In conclusion, our conducted research shows, long observation and delayed surgical intervention to prevent intraand postoperative complication are lacking substantial proof. Furthermore, analysis let us to think that performing pyeloplasty at early stage of UPJO in younger age, when is not complicated with infection leads keeping good renal function and creates best condition for further development and growth of functional structures.