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What do we know about Treatment of Post Circumcision Penile Ischemia. Case report and Review of Literature 我们对包皮环切术后阴茎缺血的治疗了解多少?病例报告及文献回顾
Pub Date : 2023-05-31 DOI: 10.32474/juns.2023.04.000189
Kopytek Weronika
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引用次数: 0
Renal Vein Thrombosis Secondary to Sepsis from Obstructive Pyelonephritis 梗阻性肾盂肾炎致败血症继发肾静脉血栓
Pub Date : 2023-05-31 DOI: 10.32474/juns.2023.04.000190
H Elkaddouri
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引用次数: 0
Successful Conservative Management of Triple Pelvic Outlet Functional Obstruction Syndrome with Voiding, Menstrual and Bowel Dysfunctions in an Adolescent Girl with long term follow up 长期随访1例少女伴排尿、月经和肠功能障碍的三重盆腔出口功能性梗阻综合征的成功保守治疗
Pub Date : 2023-01-24 DOI: 10.32474/juns.2023.04.000181
Ramnik V Patel
Our team has extensive experience of dealing with pelvic outlet triple colorectal, genital and urinary systems anatomical diseases and functional disorders, congenital and acquired involving anatomical and functional problems [1-12].
我们的团队在处理盆腔出口三重结直肠、生殖和泌尿系统解剖疾病和功能障碍,先天性和后天涉及解剖和功能问题方面具有丰富的经验[1-12]。
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引用次数: 0
Concordance between Urodynamicists: Can We Still Trust the Classification of Urofluxometry Curves? 尿动力学家之间的一致性:我们还能相信尿通量测量曲线的分类吗?
Pub Date : 2023-01-02 DOI: 10.32474/juns.2023.04.000177
Joao Antonio Pereira-Correia
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引用次数: 0
Swathed Ureter, an Enigma in Diagnosis- A Pictorial Essay 输尿管包裹,诊断中的谜题——一篇画报文章
Pub Date : 2021-10-18 DOI: 10.32474/juns.2021.03.000158
Abdul Kareem Meera Mohaideen
Urinary tract Obstruction (UTO) an alarming but common clinical condition affecting more women than men at any age, though common in 20 to 60 years of age having an overall incidence of hydronephrosis in 3.1% of autopsy. Over time, UTO results in irreversible loss of numerous nephrons leading to obstructive nephropathy and end-stage renal failure. If the obstruction of the ureter is partial and brief and if intervention is done at correct time, after relief of obstruction. complete recovery of renal function is possible. One has to be aware that UTO lasting more than 24 hours may cause irreversible loss of renal function. Radiology investigations may show UTO without ureteric dilation and dilation of ureter without UTO creating potential pitfall in radiologic diagnosis of UTO. Most of the UTO due to calculi are readily identifiable whereas many cases of ureteric exterior encasement are frequently missed from early detection even by experienced clinicians and radiologists. Failure in recognition of the encasement of ureters and causes may lead to mistaken diagnosis with resultant inappropriate management [1]. The most common benign cause of encasement of ureters is retroperitoneal fibrosis and the most frequent malignant causes are extension from an adjacent primary tumour such as sarcoma, lymphoma, (E.g.: sarcomas and lymphomas of uterus, ovaries, urinary bladder and prostate). Among benign conditions of swathed ureters, Extrinsic benign tumours, Retroperitoneal lymphadenopathy, Retroperitoneal abscess, Retroperitoneal fibrosis, Inflammatory abdominal aortic aneurysm or iliac artery aneurysm, and Endometriosis are significant. Chronic fibrosing conditions of the abdomen may involve multiple systems by their proliferative deep fibromatoses which form pseudotumor which cannot be differentiated from neoplastic conditions at imaging. Peri-ureteral inflammation (E.g.: peritonitis, salpingitis, and diverticulitis), multifocal idiopathic fibrosclerosis and schistosomiasis are some other known causes. Encasement may also be associated with blocked ureter [2-4]. Besides the inherent features of the disease causing the encasement of the ureters, in general, clinical features include recurrent fever, pain abdomen, oliguria, frequency, dysuria, haematuria nocturia, and hypertension. Patients may also present with fatigue, anorexia, weight loss, fever, hydroceles, scrotal pain, lower extremity oedema, and pulmonary embolism. Since ureters may be affected, various degrees of ureteral obstruction, hydronephrosis, and renal failure are also considered early and common clinical manifestations. In this article, we will review the four important diseases that cause ureteric encasement with some key imaging features for the diagnosis [5,6].
尿路梗阻(UTO)是一种令人担忧但常见的临床疾病,在任何年龄,女性的发病率都高于男性,尽管在20至60岁的人群中很常见,总肾积水发生率为3.1%。随着时间的推移,UTO导致大量肾单位不可逆转的损失,导致阻塞性肾病和终末期肾功能衰竭。如果输尿管梗阻是局部和短暂的,如果在正确的时间进行干预,在梗阻解除后。肾功能完全恢复是可能的。需要注意的是,UTO持续24小时以上可能会导致肾功能不可逆转的丧失。放射学检查可能显示无输尿管扩张的UTO和无UTO的输尿管扩张,这在UTO的放射学诊断中产生潜在的缺陷。大多数由结石引起的尿路囊肿很容易识别,而许多输尿管外包膜的病例即使是经验丰富的临床医生和放射科医生也经常错过早期发现。未能识别输尿管包膜及其原因可能导致误诊,从而导致治疗不当[1]。输尿管囊肿最常见的良性原因是腹膜后纤维化,最常见的恶性原因是邻近原发肿瘤(如肉瘤、淋巴瘤)的延伸(如子宫、卵巢、膀胱和前列腺的肉瘤和淋巴瘤)。在输尿管包裹的良性情况中,外源性良性肿瘤、腹膜后淋巴结病、腹膜后脓肿、腹膜后纤维化、炎症性腹主动脉瘤或髂动脉动脉瘤、子宫内膜异位症是显著的。腹部慢性纤维化可累及多个系统,其增生性深纤维瘤形成假瘤,在影像学上无法与肿瘤条件区分。输尿管周围炎症(例如:腹膜炎、输卵管炎和憩室炎)、多灶性特发性纤维硬化和血吸虫病是其他一些已知的原因。包膜也可能与输尿管阻塞有关[2-4]。除了引起输尿管堵塞的疾病的固有特征外,一般的临床特征包括反复发热、腹痛、少尿、尿频、排尿困难、血尿夜尿和高血压。患者还可能出现疲劳、厌食、体重减轻、发烧、鞘膜积液、阴囊疼痛、下肢水肿和肺栓塞。由于输尿管可能受到影响,不同程度的输尿管梗阻、肾积水、肾功能衰竭也被认为是早期和常见的临床表现。在本文中,我们将回顾导致输尿管梗阻的四种重要疾病以及诊断的一些关键影像学特征[5,6]。
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引用次数: 0
Efficacy of Qurmin on Post-Operative Lower Urinary Tract Symptoms After Photoselective Vaporization of the Prostate: A Multicentre Case-Control Study 高敏对前列腺光选择性汽化术后下尿路症状的疗效:一项多中心病例对照研究
Pub Date : 2021-01-01 DOI: 10.13188/2380-0585.1000031
R. Lombardo, Destefanis, Varvello, Oriti, Tuccio, Ruggera, D. Rienzo, C. DeNunzio
Objective: To evaluate the efficacy of highly bioavailable curcumin complex on postoperative lower urinary symptoms in patients treated with photoselective vaporization of the prostate (PVP) for lower urinary tract symptoms and benign prostatic enlargement (LUTS/BPE) in a multicentre randomized controlled study. Materials and Methods: A consecutive series of patients with LUTS-BPE undergoing PVP were enrolled. Patients were randomized in a 2:1 ratio to oral highly bioavailable curcumin complex (Qurmin®, Naturneed, Italy), twice a day for 10 days then once daily for 20 days postoperatively or no treatment. Clinical and demographic characteristics of all patients were collected. Patients were evaluated preoperatively, on day 1 (after catheter removal), on day 15 and on day 30 using the International Prostate Symptom Score (IPSS), National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and Pain Urgency Frequency (PUF) questionnaires to assess the efficacy of the treatment. Results: Overall 106 patients were randomized to curcumin complex treatment (71/106:67%) or no treatment (35/106:33%). Preoperatively no significant differences in terms of age, PV, IPSS; Qmax, NIH-CPSI and PUF were recorded. Patients in both groups presented improvements in terms of IPSS, NIH-CPSI and PUF scores on day 15 and on day 30 when compared to day 1 (p<0,01). On day 15 patients on active treatment group presented a better improvement in terms of urinary symptoms (Δ15-1 IPSS score: 6,0 ± 7,6 vs 3,1 ± 4,6, p=0,001) and pain (Δ15-1 PUF pain : 1,7 ± 4,2 vs -0,8 ± 4,1, p=0,001). As well on day 30 patients on active treatment group presented a better improvement in terms of urinary symptoms (Δ30-1 IPSS score: 9,0 ± 7,6 vs 6,2 ± 6,4, p=0,001) and pain (Δ30-1 PUF pain: 3,3 ± 5,3 vs 1,6 ± 4,5, p=0,001). No significant differences in terms of NIH-CPS improvements were recorded between groups. No adverse events or side effects have been recorded in the treated group. Conclusions: Patients treated with highly bioavailable curcumin complex after PVP reported a significantly better improvement in symptoms and pain when compared to no treatment. Further studies should confirm our results.
目的:在一项多中心随机对照研究中,评价高生物利用度姜黄素复合物对下尿路症状和良性前列腺增大(LUTS/BPE)患者行前列腺光选择性汽化(PVP)治疗后下尿路症状的疗效。材料与方法:纳入了一系列连续的LUTS-BPE患者进行PVP治疗。患者以2:1的比例随机分配到口服高生物利用度姜黄素复合物(Qurmin®,Naturneed,意大利),每天两次,持续10天,然后每天一次,持续20天,术后或未治疗。收集所有患者的临床和人口学特征。术前、拔管后第1天、第15天和第30天分别采用国际前列腺症状评分(IPSS)、美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)和疼痛急迫频率(PUF)问卷对患者进行评估,以评估治疗效果。结果:106例患者随机分为姜黄素复合治疗组(71/106:67%)和不治疗组(35/106:33%)。术前年龄、PV、IPSS差异无统计学意义;记录Qmax、NIH-CPSI、PUF。与第1天相比,两组患者在第15天和第30天的IPSS、NIH-CPSI和PUF评分均有改善(p< 0.01)。第15天,积极治疗组患者在泌尿系统症状(Δ15-1 IPSS评分:6,0±7,6 vs 3,1±4,6,p= 0.001)和疼痛(Δ15-1 PUF疼痛:1,7±4,2 vs -0,8±4,1,p= 0.001)方面有较好的改善。同时,在第30天,积极治疗组患者在泌尿系统症状(Δ30-1 IPSS评分:9,0±7,6比6,2±6,4,p= 0.001)和疼痛(Δ30-1 PUF疼痛:3,3±5,3比1,6±4,5,p= 0.001)方面均有较好的改善。在NIH-CPS改善方面,两组间无显著差异。治疗组无不良事件或副作用记录。结论:PVP后接受高生物利用度姜黄素复合物治疗的患者与未接受治疗的患者相比,症状和疼痛的改善明显更好。进一步的研究将证实我们的结果。
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引用次数: 0
The Therapeutic Ladder - A Clinician and a Patient Perspective 治疗阶梯-临床医生和患者的观点
Pub Date : 2021-01-01 DOI: 10.13188/2380-0585.1000032
V. Daniels-Hepnar
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引用次数: 0
MicroRNA and messenger RNA As Potential Urinary Biomarkers in Prostate Cancer 微RNA和信使RNA作为前列腺癌潜在的尿液生物标志物
Pub Date : 2020-12-30 DOI: 10.13188/2380-0585.1000029
Mubarika, Haryana
Prostate Cancer (PCa) isthe fifth leading cause of death worldwide and the second most common cancer in men. Worldwide, it was estimated that around 1,276,106 newly diagnosed PCa were reported in 2018 [1]. The diagnosis of suspected PCa is made when the abnormality from the Digital Rectal Examination (DRE) and elevated Prostate Specific Antigen (PSA) present [2]. PSA value of morethan 4 ng/mlisan indication for prostate biopsy examination and this border line value hasa positive predictive value of only 37%, and a negative predictive value of 91% [2]. Therefore, rigorous studies searching for new biomarkers with non-invasive methods that have higher specificity than PSA and can be used as an early detectors as well as prognostic predictors of PCa, have emerged [3].
前列腺癌(PCa)是全球第五大死亡原因,也是男性第二大常见癌症。据估计,2018年全球新诊断的PCa约为1,276,106例[1]。当直肠指检(DRE)出现异常和前列腺特异抗原(PSA)升高时,可诊断为疑似PCa[2]。PSA值大于4 ng/ml是前列腺活检检查的指征,该分界线值的阳性预测值仅为37%,阴性预测值为91%[2]。因此,已经出现了严谨的研究,以非侵入性方法寻找新的生物标志物,这些标志物具有比PSA更高的特异性,可以用作PCa的早期检测器和预后预测因子[3]。
{"title":"MicroRNA and messenger RNA As Potential Urinary Biomarkers in Prostate Cancer","authors":"Mubarika, Haryana","doi":"10.13188/2380-0585.1000029","DOIUrl":"https://doi.org/10.13188/2380-0585.1000029","url":null,"abstract":"Prostate Cancer (PCa) isthe fifth leading cause of death worldwide and the second most common cancer in men. Worldwide, it was estimated that around 1,276,106 newly diagnosed PCa were reported in 2018 [1]. The diagnosis of suspected PCa is made when the abnormality from the Digital Rectal Examination (DRE) and elevated Prostate Specific Antigen (PSA) present [2]. PSA value of morethan 4 ng/mlisan indication for prostate biopsy examination and this border line value hasa positive predictive value of only 37%, and a negative predictive value of 91% [2]. Therefore, rigorous studies searching for new biomarkers with non-invasive methods that have higher specificity than PSA and can be used as an early detectors as well as prognostic predictors of PCa, have emerged [3].","PeriodicalId":17651,"journal":{"name":"Journal of Urology & Nephrology Studies","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75474239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Failure from CastNephropathy: Role of Plasmapheresis 卡斯特肾病肾衰:血浆置换的作用
Pub Date : 2019-06-30 DOI: 10.13188/2380-0585.1000026
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引用次数: 0
Employment Status of Patients with ESRD and the Subsequent treatment modalities in the United State 美国ESRD患者的就业状况及后续治疗方式
Pub Date : 2019-03-11 DOI: 10.32474/JUNS.2019.01.000119
J. Sullivan
End Stage Renal Disease impacts the lives of over 725,000 Americans and their families. In 1972, despite the cost of supporting a rapidly growing chronic condition at the time, the United States initiated a system whereby everyone would be treated that qualifies for social security benefits, after a waiting period of three years (Medicare Secondary Payer was slowly extended over the years to 36 months after diagnosis as it currently stands), regardless of age, providing the platform for the debate of a potential nationalized health care system that currently seems to be in a period of uncertainty. However, over three decades through significant consolidation, the treatment of dialysis via two large provider chains (one fully integrated) have directed patients to hemodialysis in the out-patient setting without considering the technological or clinical benefits of home hemodialysis or peritoneal dialysis [1,2]. This may have occurred as a result of medical training although the overall system is structured more on a corporate basis today with new nephrologists joining practices that are already contracted with a large chain through medical directorships. That said, patients seem to be directed towards outpatient hemo-dialysis over other options such as home hemo-dialysis and peritoneal dialysis. The result has created an economic and medical system that has shifted toward what is perceived as the lowest cost of care without a consideration for other treatment modalities that promote a better quality of life for the patient as well as greater monetary benefits for the United States Federal Government. From a pure economic standpoint, profitability for providers is in the out-patient clinics despite the initial investment of $1-2 million to build out a clinic via fixed asset utilization and the variable cost of peritoneal dialysis as well as the supply costs needed for home hemodialysis. In other words, for these two treatment modalities, the margin, if any, is built purely into the treatment. Margins can be enhanced through high utilization of in-center facilities via leveraging the staff and fixed costs while using economies of scale to reduce variable costs such as dialyzers and lines combined with a favorable commercial patient base. With the focus on this modality, there are economic impacts based on decisions that increase the overall expenditures to the entire system that can easily be avoided or reduced.
终末期肾病影响着超过72.5万美国人及其家人的生活。1972年,尽管当时支持快速增长的慢性疾病的费用很高,但美国启动了一项制度,在经过三年的等待期(医疗保险第二支付人多年来慢慢延长到目前诊断后的36个月)后,无论年龄大小,每个人都可以接受有资格享受社会保障福利的治疗。为目前似乎处于不确定时期的潜在国有化医疗保健系统的辩论提供了平台。然而,经过三十年的显著整合,透析治疗通过两个大型供应商链(一个完全整合)引导患者在门诊进行血液透析,而没有考虑家庭血液透析或腹膜透析的技术或临床益处[1,2]。这可能是医疗培训的结果,尽管今天整个系统的结构更多地以企业为基础,新的肾病学家加入已经通过医疗董事与大型连锁签约的实践。也就是说,患者似乎更倾向于门诊血液透析而不是其他选择,如家庭血液透析和腹膜透析。其结果是创造了一个经济和医疗系统,它转向了被认为是最低成本的护理,而没有考虑到其他治疗方式,这些治疗方式可以提高患者的生活质量,并为美国联邦政府带来更大的经济利益。从纯粹的经济角度来看,尽管通过固定资产利用和腹膜透析的可变成本以及家庭血液透析所需的供应成本,建立诊所的初始投资为1- 200万美元,但提供者的盈利能力在于门诊诊所。换句话说,对于这两种治疗方式,边际,如果有的话,是完全建立在治疗。通过充分利用员工和固定成本,提高中心设施的利用率,同时利用规模经济来降低诸如透析器和生产线等可变成本,并结合有利的商业患者基础,可以提高利润率。随着对这种模式的关注,基于增加整个系统总体支出的决策的经济影响可以很容易地避免或减少。
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引用次数: 0
期刊
Journal of Urology & Nephrology Studies
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