Effect of dietary anthocyanins on biomarkers of type 2 diabetes and related obesity: A systematic review and meta-analysis.

IF 7.3 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Critical reviews in food science and nutrition Pub Date : 2024-07-01 Epub Date: 2023-03-12 DOI:10.1080/10408398.2023.2186121

Vandita Tiwari, Saloni Sharma, Apoorv Tiwari, Bhawna Sheoran, Satveer Kaur, Anjali Sharma, Mona Yadav, Archana Bhatnagar, Monika Garg

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Abstract

Anthocyanins have been reported for the protective effects against type 2 diabetes and related obesity. This meta-analysis examined the benefits of anthocyanins on type 2 diabetes and obesity biomarkers in animals and humans. The study included 21 clinical trials and 27 pre-clinical studies. A systematic search was conducted using the following inclusion criteria: in vivo rodent studies; human randomized clinical trials, both aimed at assessing the fasting blood glucose (FBG), HbA1c, total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein; and study duration of at least two weeks. Out of the 201 examined publications, 48 were shortlisted after implementation of the selection criteria. Results of clinical trials demonstrated that consumption of anthocyanin-rich food significantly reduced the FBG (p < 0.0001), HbA1c (p = 0.02), TC (p = 0.010), TG (p = 0.003), LDL (p = 0.05) and increases the HDL (p = 0.03) levels. Similarly, pre-clinical studies demonstrated the amelioration of the HbA1c (p = 0.02), FBG, TC, TG, and LDL (p < 0.00001), with non-significant changes in the HDL (p = 0.11). Sub-group analysis indicated dose-dependent effect. This compilation confirms that consuming anthocyanin-rich foods positively correlates with the reduction in the blood glucose and lipid levels in diabetic and obese subjects.

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膳食花青素对 2 型糖尿病及相关肥胖症生物标志物的影响：系统回顾和荟萃分析。

据报道，花青素对 2 型糖尿病和相关肥胖症有保护作用。这项荟萃分析研究了花青素对动物和人类 2 型糖尿病和肥胖生物标志物的益处。研究包括 21 项临床试验和 27 项临床前研究。采用以下纳入标准进行了系统检索：体内啮齿动物研究；人类随机临床试验，均以评估空腹血糖 (FBG)、HbA1c、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白为目的；研究持续时间至少两周。在 201 篇受检出版物中，有 48 篇在执行筛选标准后入围。临床试验结果表明，食用富含花青素的食物可显著降低 FBG（p p = 0.02）、TC（p = 0.010）、TG（p = 0.003）、LDL（p = 0.05）水平，提高 HDL（p = 0.03）水平。同样，临床前研究表明，HbA1c（p = 0.02）、FBG、TC、TG 和 LDL（p = 0.11）均有所改善。分组分析表明其效果与剂量有关。该汇编证实，食用富含花青素的食物与降低糖尿病和肥胖受试者的血糖和血脂水平呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.