Photodynamic activity of water dispersion of gold nanoparticles for treating experimental purulent wounds

Abstract

Introduction. Antimicrobial photodynamic therapy is one of the highly effective techniques for treating infectious lesions of the skin and soft tissues. However, the search for safe photosensitizers remains relevant.Purpose: to study the application of aqueous dispersion of gold nanoparticles as a potential photosensitizer for antimicrobial photodynamic therapy in experimental purulent wounds.Material and methods. Photosensitizing ability of aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol was studied on experimental full-thickness purulent wounds in rats. Semiconductor laser (Alcom Medica, St. Petersburg) with wavelength 405 nm was used.Results. It has been found out that pretreatment of wounds with nanostructures followed by photodynamic exposure gives a 1.6-fold reduction of healing process of wound defects in laboratory animals compared to the control group. in experimental animals, an effective cleansing of wounds from purulent contents was observed as well.Conclusion. An aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol can be considered as an effective photosensitizer for antimicrobial photodynamic therapy.