Akshaya Srikanth Bhagavathula, Shahd Ayman Refaat, Barry L Bentley, Jamal Rahmani
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引用次数: 3
Abstract
High dietary sodium and low potassium intake is associated with high blood pressure (BP). The current study aimed to determine if the sodium-to-potassium ratio is more strongly associated with low (130-139/80-89 mm Hg) and high (≥140/90 mm Hg) BP thresholds among US adults than either sodium or potassium alone. A total of 30,776 patients aged ≥20 years with complete blood pressure participated in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Demographic information and health characteristics were compared between men and women using the chi-square test for categorical variables and independent samples t-test for continuous variables. Logistic regression was performed to investigate the association of the odds ratios (OR) of different levels of sodium, potassium, and sodium-to-potassium ratio. After multivariable adjustment (age, gender, Body mass index, Smoking, education, Race, Alcohol, total energy intake, and physical activity), no relationship has been observed between high versus low sodium-to-potassium ratio and BP threshold of 130-139/80-89 mm Hg (odds ratio [OR]: 1.02, 95% confidence interval [CI]: 0.92-1.12). Higher sodium-to-potassium ratio (OR=1.24; CI: 1.11-1.38) and dietary intake of potassium (OR=0.66; CI: 0.55-0.80) showed significant association in reducing the BP threshold of ≥140/90 mm Hg. In dose-response analysis, higher BP ≥140/90 mm Hg was inversely associated with higher potassium intake. Furthermore, the sodium-to-potassium ratio showed higher odds in predicting the BP of patients aged ≤60 years, underweight, nonsmokers, and non-alcohol users. The study confirms an inverse association between higher potassium intake and higher BP threshold. The Doses-response analyses showed sodium-to-potassium ratio is a better predictor of BP thresholds than sodium or potassium alone.
高钠低钾饮食摄入与高血压有关。目前的研究旨在确定在美国成年人中,钠钾比与低(130-139/80-89 mm Hg)和高(≥140/90 mm Hg)血压阈值的相关性是否比单独的钠或钾更强。2003年至2018年,共有30776名年龄≥20岁的完全性血压患者参加了国家健康与营养检查调查(NHANES)。使用分类变量的卡方检验和连续变量的独立样本t检验对男性和女性的人口统计信息和健康特征进行比较。采用Logistic回归研究不同钠、钾和钠钾比水平的比值比(OR)之间的相关性。经过多变量调整(年龄、性别、体重指数、吸烟、教育、种族、酒精、总能量摄入和体育活动)后,高钠钾比和低钠钾比与130-139/80-89毫米汞柱的血压阈值之间没有关系(比值比[OR]:1.02,95%置信区间[CI]:0.92-1.12)。较高的钠钾比(OR=1.24;CI:1.11-1.38)和膳食钾摄入量(OR=0.66;CI:0.55-0.80)显示出降低≥140/90毫米汞柱血压阈值的显著相关性。在剂量反应分析中,血压≥140/90 mm Hg的越高与钾摄入量越高呈负相关。此外,钠钾比在预测年龄≤60岁、体重不足、不吸烟和非酒精使用者的血压方面显示出更高的几率。这项研究证实了较高的钾摄入量和较高的血压阈值之间的反比关系。剂量反应分析表明,钠钾比单独使用钠或钾更能预测血压阈值。
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
The editorial and advisory boards include many of the leading persons currently working in this area.
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