The use of vitamin D for patients with inflammatory bowel diseases.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS International Journal for Vitamin and Nutrition Research Pub Date : 2024-02-01 Epub Date: 2022-08-26 DOI:10.1024/0300-9831/a000764
Júlia Novaes Matias, Vinícius Marinho Lima, Giovanna Soares Nutels, Lucas Fornari Laurindo, Sandra Maria Barbalho, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Rodrigo Buzinaro Suzuki, Elen Landgraf Guiguer
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Abstract

As vitamin D (VD) plays an essential role in inflammatory bowel diseases (IBD), this systematic review aimed to update the participation of this vitamin in the prevention or remission of these diseases. This review has included studies in MEDLINE-PubMed, EMBASE, and Cochrane databases. The authors have followed PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines. According to the inclusion and exclusion criteria, twenty-two randomized clinical trials were selected. In total, 1,209 patients were included in this systematic review: 1034 received only VD and 175 received VD in combination with calcium. The average doses of VD supplementation were from oral 400 IU daily to 10,000 IU per kilogram of body weight. Single injection of 300,000 IU of VD was also used. Several studies have shown the crucial role that VD plays in the therapeutic approach of IBD due to its effects on the immune system. It effectively decreased inflammatory cytokines such as TNF-α and IFN-γ (p<0.05) and provided a reduction in disease activity assessed through different scores such as Crohn's Disease Activity Index (CDAI) (p<0.05) and Ulcerative Colitis Disease Activity Index (UCDAI) (p<0.05). Unfortunately, the available clinical trials are not standardized for of doses and routes of administration. Existing meta-analyses are biased because they compare studies using different doses or treatments in combination with different drugs or supplements such as calcium. Even though VD has crucial effects on inflammatory processes, there is still a need for standardized studies to establish how the supplementation should be performed and the doses to be administered.

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对炎症性肠病患者使用维生素 D。
由于维生素 D(VD)在炎症性肠病(IBD)中起着至关重要的作用,本系统综述旨在更新这种维生素在预防或缓解这些疾病中的作用。本综述纳入了 MEDLINE-PubMed、EMBASE 和 Cochrane 数据库中的研究。作者遵循了 PRISMA(系统综述和元分析的首选报告项目)指南。根据纳入和排除标准,共筛选出 22 项随机临床试验。本系统综述共纳入了 1209 名患者:其中 1034 名患者只服用了 VD,175 名患者在服用 VD 的同时还服用了钙剂。补充 VD 的平均剂量从每天口服 400 IU 到每公斤体重 10,000 IU 不等。此外,还采用了单次注射 30 万国际单位 VD 的方法。多项研究表明,由于 VD 对免疫系统的影响,它在 IBD 的治疗方法中发挥着至关重要的作用。它能有效降低炎症细胞因子,如 TNF-α 和 IFN-γ(p
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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