THE ROLE OF DIFFERENTIAL MARKERS CD 200, CD103, CD11C IN THE DIAGNOSIS OF CHRONIC B-LYMPHOPROLIFERATIVE DISEASES BY FLOW CYTOMETRY: A LITERATURE REVIEW

Abstract

Relevance: Immunophenotyping with multiparameter flow cytofluorimetry allows differentiating classical variants of chronic B-lymphoproliferative diseases. However, some atypical conditions are hard to interpret; they gave rise to the search for new differential markers. The study aimed to analyze the predictive value of monoclonal markers CD200, CD103, and CD11c in differential diagnostics of hairy cell leukemia, splenic marginal zone lymphoma, and splenic mantle zone lymphoma. Methods: We studied open access articles with a search depth of 10 years using the following databases of scientific publications and specialized search engines: PubMed, Google Scholar, Cochrane Library, Web of Science, Scopus, Сyberleninka, and the eLIBRARY electronic library. As a result, 30 literary sources were identified, of which eight publications were the basis of the analytical material for this article. Inclusion criteria: Evidence level A, B publications: meta-analyses, systematic reviews, cohort, and cross-sectional studies. Exclusion criteria: expert opinion in the form of short messages or promotional articles. Results: We revealed a different degree of informativeness of some traditional markers in immunophenotypic diagnostics of B-cell lymphoproliferative diseases by flow cytometry; the use of additional differential markers CD200, CD103, and CD11c showed their high informativeness in differential diagnostics between different variants of B-cell lymphoproliferative diseases with initial immunophenotypic and morphological characteristics of lymphoid elements. Conclusion: Analysis of the selected publications gives grounds to improve the multiparametric panel for differential diagnostics of chronic B-lymphoproliferative diseases.