Managing Follicular Lymphoma in the Elderly Population.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Case Reports in Medicine Pub Date : 2023-01-01 DOI:10.1155/2023/1038934
Jiao Jie Cherie Tan, Yuen Lei Sze, Clarice Choong Shi Hui
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Abstract

Follicular lymphoma (FL) is one of the most commonly diagnosed types of indolent non-Hodgkin lymphoma (NHL). The median age of diagnosis for FL is 65 years old. Although the median life expectancy after diagnosis is approximately 10 years, the incurable disease has a high risk of transformation. This case report focuses on an 80-year-old patient diagnosed with low-grade follicular lymphoma which subsequently transformed leading to the patient's eventual demise as the patient took on the palliative intent. This case report aims to highlight the importance of clinical markers or prognostic factors to identify patients, specifically the elderly population who are at risk of transformation to aggressive forms when their FL remains at stage I-II phases. Currently, elderly patients with FL tend to be quickly dismissed with curative intent with chemotherapy, given their age and comorbidities, despite forming the majority of the population with follicular lymphoma. Age more than 60 years old has been shown to be one of the most powerful yet poor prognostic features in follicular lymphoma international prognostic index (FLIPI)-the main scoring system used for FL. Hence, further studies are required to look into the tailoring treatment for elderly patients with follicular lymphoma after risk stratifying them with appropriate clinical and prognostic markers.

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老年人群滤泡性淋巴瘤的管理。
滤泡性淋巴瘤(FL)是一种最常见的诊断类型的惰性非霍奇金淋巴瘤(NHL)。FL的中位诊断年龄为65岁。虽然诊断后的平均预期寿命约为10年,但这种无法治愈的疾病有很高的转化风险。本病例报告的重点是一位80岁的低级别滤泡性淋巴瘤患者,随着患者接受姑息治疗,该患者随后发生转变,导致患者最终死亡。本病例报告旨在强调临床标志物或预后因素对识别患者的重要性,特别是老年人群,当他们的FL仍处于I-II期时,他们有转变为侵袭性形式的风险。目前,尽管在滤泡性淋巴瘤患者中占多数,但考虑到年龄和合并症,老年FL患者往往很快被排除在化疗的治疗目的之外。年龄超过60岁已被证明是滤泡性淋巴瘤国际预后指数(FLIPI)中最重要但预后较差的特征之一,这是滤泡性淋巴瘤的主要评分系统。因此,需要进一步的研究,在使用适当的临床和预后标志物对老年滤泡性淋巴瘤患者进行风险分层后,对其进行定制治疗。
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来源期刊
Case Reports in Medicine
Case Reports in Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
1.70
自引率
0.00%
发文量
53
审稿时长
13 weeks
期刊最新文献
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