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Severe Pulmonary Blastomycosis in a Young Adult: Probable Role of E-Cigarette Use in Immunosuppression.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI: 10.1155/carm/6019638
Rajat Gupta, Barath Prashanth Sivasubramanian, Ajay Sriram Antony Raj, Sudha Dirisanala, Tahani Dakkak, Ashley Williams, Navneeth Bongu

Background: E-cigarette use has become increasingly prevalent among young adults, raising concerns about its potential health impact and susceptibility to infections. Blastomyces dematitidis, the causative agent of blastomycosis, is a dimorphic fungus endemic to certain regions of the United States. We present a rare presentation of pulmonary blastomycosis in a young, immunocompetent male with chronic e-cigarette use, highlighting the need to consider fungal infections in the differential diagnosis of pneumonia of unknown etiology in patients with risk factors for respiratory illness. Presentation: A 20-year-old male with a 4-year history of daily e-cigarette use and gutter cleaner by occupation presented with a 10-day history of worsening cough, bloody sputum, shortness of breath, night sweats, fever, and weight loss. He was hemodynamically stable, required minimal oxygen support, and was admitted for chest X-ray showing right upper lobe pneumonia and cavitary lesion. The patient was tested for community-acquired pneumonia, atypical pneumonia, granulomatous diseases, and immunosuppressive and viral lymphoproliferative disorders. A diagnostic bronchoscopy ultimately confirmed blastomycosis, leading to treatment with amphotericin B and itraconazole, resulting in significant clinical improvement. Conclusion: Pulmonary blastomycosis often presents asymptomatically, with severe cases more common in the elderly or those with comorbidities and immune dysfunction. Physicians tend to overlook it as a differential diagnosis for primary lung infections, focusing on bacterial pneumonia and tuberculosis in younger individuals. This case underscores the need for further investigation into the impact of e-cigarette use on immune function. This case also highlights the importance of making blastomycosis a reportable disease in Georgia, considering its increasing incidence and the widespread construction and soil disturbance occurring throughout the state.

{"title":"Severe Pulmonary Blastomycosis in a Young Adult: Probable Role of E-Cigarette Use in Immunosuppression.","authors":"Rajat Gupta, Barath Prashanth Sivasubramanian, Ajay Sriram Antony Raj, Sudha Dirisanala, Tahani Dakkak, Ashley Williams, Navneeth Bongu","doi":"10.1155/carm/6019638","DOIUrl":"https://doi.org/10.1155/carm/6019638","url":null,"abstract":"<p><p><b>Background:</b> E-cigarette use has become increasingly prevalent among young adults, raising concerns about its potential health impact and susceptibility to infections. <i>Blastomyces dematitidis</i>, the causative agent of blastomycosis, is a dimorphic fungus endemic to certain regions of the United States. We present a rare presentation of pulmonary blastomycosis in a young, immunocompetent male with chronic e-cigarette use, highlighting the need to consider fungal infections in the differential diagnosis of pneumonia of unknown etiology in patients with risk factors for respiratory illness. <b>Presentation:</b> A 20-year-old male with a 4-year history of daily e-cigarette use and gutter cleaner by occupation presented with a 10-day history of worsening cough, bloody sputum, shortness of breath, night sweats, fever, and weight loss. He was hemodynamically stable, required minimal oxygen support, and was admitted for chest X-ray showing right upper lobe pneumonia and cavitary lesion. The patient was tested for community-acquired pneumonia, atypical pneumonia, granulomatous diseases, and immunosuppressive and viral lymphoproliferative disorders. A diagnostic bronchoscopy ultimately confirmed blastomycosis, leading to treatment with amphotericin B and itraconazole, resulting in significant clinical improvement. <b>Conclusion:</b> Pulmonary blastomycosis often presents asymptomatically, with severe cases more common in the elderly or those with comorbidities and immune dysfunction. Physicians tend to overlook it as a differential diagnosis for primary lung infections, focusing on bacterial pneumonia and tuberculosis in younger individuals. This case underscores the need for further investigation into the impact of e-cigarette use on immune function. This case also highlights the importance of making blastomycosis a reportable disease in Georgia, considering its increasing incidence and the widespread construction and soil disturbance occurring throughout the state.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"6019638"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Ipsilateral Adrenal and Retroperitoneal Ganglioneuroma: A Unique Case of Large Tumor Mass.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI: 10.1155/carm/7440806
Abdolreza Mohammadi, Fardin Asgari, Ehsan Zemanati Yar, Mina Rezayat, Mahdi Najarzadegan, Seyed Mohammad Kazem Aghamir

This case report presents a rare instance of synchronous adrenal ganglioneuroma and an ipsilateral retroperitoneal mass in a 51-year-old woman with episodic hypertensive crises and increased symptom frequency. Imaging revealed a hypodense mass near the right kidney and an additional adrenal mass, which led to surgical intervention. Laboratory findings indicated hypercortisolism, and both masses were surgically removed by the laparoscopy approach. Postoperative pathology identified both masses as maturing-type ganglioneuroma, with no signs of malignancy or complications. This case highlights the diagnostic and therapeutic challenges of such rare presentations and emphasizes the importance of detailed imaging, surgical excision, and histopathological analysis. The potential link between elevated cortisol levels and ganglioneuroma, as observed here, underscores the need for further research into these benign tumors.

{"title":"Synchronous Ipsilateral Adrenal and Retroperitoneal Ganglioneuroma: A Unique Case of Large Tumor Mass.","authors":"Abdolreza Mohammadi, Fardin Asgari, Ehsan Zemanati Yar, Mina Rezayat, Mahdi Najarzadegan, Seyed Mohammad Kazem Aghamir","doi":"10.1155/carm/7440806","DOIUrl":"https://doi.org/10.1155/carm/7440806","url":null,"abstract":"<p><p>This case report presents a rare instance of synchronous adrenal ganglioneuroma and an ipsilateral retroperitoneal mass in a 51-year-old woman with episodic hypertensive crises and increased symptom frequency. Imaging revealed a hypodense mass near the right kidney and an additional adrenal mass, which led to surgical intervention. Laboratory findings indicated hypercortisolism, and both masses were surgically removed by the laparoscopy approach. Postoperative pathology identified both masses as maturing-type ganglioneuroma, with no signs of malignancy or complications. This case highlights the diagnostic and therapeutic challenges of such rare presentations and emphasizes the importance of detailed imaging, surgical excision, and histopathological analysis. The potential link between elevated cortisol levels and ganglioneuroma, as observed here, underscores the need for further research into these benign tumors.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"7440806"},"PeriodicalIF":0.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Pulsed Nd:YAG Laser for the Treatment of Classic Kaposi Sarcoma.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-23 eCollection Date: 2025-01-01 DOI: 10.1155/carm/9034642
Domenico Piccolo, Laura Pieri, Irene Fusco, Tiziano Zingoni, Claudio Conforti, Sabrina Tramontozzi

Background: Classic Kaposi's sarcoma (CKS) is distinguished by nodules and clustered papules over the extremities with persistent edema. Aim: This report examine the results of neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser for the treatment of numerous nodular symptomatic nodules in CKS patients' lower extremities that are ineligible for systemic therapy. Methods: Each lesion received two sessions Nd:YAG laser treatment performed at 1-month intervals. Pretreatment and follow-up visit (after 3 months) were accompanied by clinical photographs and improvement was assessed by a skilled medical professional by comparing before- and after-treatment photos as well as by looking at patients directly. Videodermoscopy was performed on all lesions. Results: Just one session with long-pulsed Nd:YAG laser proved to be successful, with the immediate coagulation of the lesions and the disappearance of most of them. Every single lesion healed in two to 4 weeks. Only one lesion, the largest one, presented a water blister after treatment, which resolved within a few days. At 2 months follow up, the patient reported total pain relief and full recovery after the symptomatic nodules vanished. Conclusion: Nd:YAG laser could represent a rapid and advantageous therapeutic approach for both early- and advanced-stage CKS patients.

{"title":"Long-Pulsed Nd:YAG Laser for the Treatment of Classic Kaposi Sarcoma.","authors":"Domenico Piccolo, Laura Pieri, Irene Fusco, Tiziano Zingoni, Claudio Conforti, Sabrina Tramontozzi","doi":"10.1155/carm/9034642","DOIUrl":"10.1155/carm/9034642","url":null,"abstract":"<p><p><b>Background:</b> Classic Kaposi's sarcoma (CKS) is distinguished by nodules and clustered papules over the extremities with persistent edema. <b>Aim:</b> This report examine the results of neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser for the treatment of numerous nodular symptomatic nodules in CKS patients' lower extremities that are ineligible for systemic therapy. <b>Methods:</b> Each lesion received two sessions Nd:YAG laser treatment performed at 1-month intervals. Pretreatment and follow-up visit (after 3 months) were accompanied by clinical photographs and improvement was assessed by a skilled medical professional by comparing before- and after-treatment photos as well as by looking at patients directly. Videodermoscopy was performed on all lesions. <b>Results</b>: Just one session with long-pulsed Nd:YAG laser proved to be successful, with the immediate coagulation of the lesions and the disappearance of most of them. Every single lesion healed in two to 4 weeks. Only one lesion, the largest one, presented a water blister after treatment, which resolved within a few days. At 2 months follow up, the patient reported total pain relief and full recovery after the symptomatic nodules vanished. <b>Conclusion:</b> Nd:YAG laser could represent a rapid and advantageous therapeutic approach for both early- and advanced-stage CKS patients.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"9034642"},"PeriodicalIF":0.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombocytopenia and Epistaxis Complicating Plasmodium falciparum Malaria: Case Report Study.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.1155/carm/6670368
Mugahid A Mobark

Malaria is one of the vector-borne diseases with major public health problems to date, especially in endemic areas. Malaria is usually associated with various degrees of reduced red blood counts, and thrombocytopenia is a common association of malaria, but it is rarely associated with hemorrhagic manifestations. This case report presents two Sudanese patients, who presented to a private clinic in North Bahri. The patients were infected with Plasmodium falciparum; they developed thrombocytopenia and were presented clinically with epistaxis. A 36-year-old male and a 41-year-old male presented with the clinical features of malaria and epistaxis and were diagnosed with P. falciparum malaria. Both patients had significant thrombocytopenia in complete blood count (CBC). They showed clinical and laboratory improvement of thrombocytopenia after successful treatment of malaria. Although bleeding is a rare complication of malaria associated with thrombocytopenia, it should be considered even if it presents as a minor bleeding such as epistaxis or bleeding from gum.

{"title":"Thrombocytopenia and Epistaxis Complicating <i>Plasmodium falciparum</i> Malaria: Case Report Study.","authors":"Mugahid A Mobark","doi":"10.1155/carm/6670368","DOIUrl":"10.1155/carm/6670368","url":null,"abstract":"<p><p>Malaria is one of the vector-borne diseases with major public health problems to date, especially in endemic areas. Malaria is usually associated with various degrees of reduced red blood counts, and thrombocytopenia is a common association of malaria, but it is rarely associated with hemorrhagic manifestations. This case report presents two Sudanese patients, who presented to a private clinic in North Bahri. The patients were infected with <i>Plasmodium falciparum</i>; they developed thrombocytopenia and were presented clinically with epistaxis. A 36-year-old male and a 41-year-old male presented with the clinical features of malaria and epistaxis and were diagnosed with <i>P. falciparum</i> malaria. Both patients had significant thrombocytopenia in complete blood count (CBC). They showed clinical and laboratory improvement of thrombocytopenia after successful treatment of malaria. Although bleeding is a rare complication of malaria associated with thrombocytopenia, it should be considered even if it presents as a minor bleeding such as epistaxis or bleeding from gum.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"6670368"},"PeriodicalIF":0.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report of Inguinal Hernia Sac Lithiasis.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.1155/carm/6658363
Kiana Babaei, Ali Movahedi, Azam Gazerani, Navid Soroush

We report a case of a stone in inguinal hernia sac. A 41-year-old male patient presented to Hakim Hospital in Neyshabur city, Iran, with complaints of pain and swelling in the right abdominal region. After initial evaluations, a diagnosis of right inguinal hernia was made, and the patient was scheduled for hernioplasty. He had no history of previous surgeries, hospital admissions, underlying diseases, or kidney and gallbladder stones. The surgery was performed. The hernia sac was exposed. Inside the hernia sac, a stone measuring approximately 2 cm in diameter, with a hard consistency and yellow color, was found. The stone was not adherent to the sac and was mobile. The hernia sac was opened, the stone was removed, and sent to the pathology lab. The patient was discharged 24 h later in good general condition. According to the pathology report, the components of the stone were identified as calcium oxalate.

{"title":"A Case Report of Inguinal Hernia Sac Lithiasis.","authors":"Kiana Babaei, Ali Movahedi, Azam Gazerani, Navid Soroush","doi":"10.1155/carm/6658363","DOIUrl":"10.1155/carm/6658363","url":null,"abstract":"<p><p>We report a case of a stone in inguinal hernia sac. A 41-year-old male patient presented to Hakim Hospital in Neyshabur city, Iran, with complaints of pain and swelling in the right abdominal region. After initial evaluations, a diagnosis of right inguinal hernia was made, and the patient was scheduled for hernioplasty. He had no history of previous surgeries, hospital admissions, underlying diseases, or kidney and gallbladder stones. The surgery was performed. The hernia sac was exposed. Inside the hernia sac, a stone measuring approximately 2 cm in diameter, with a hard consistency and yellow color, was found. The stone was not adherent to the sac and was mobile. The hernia sac was opened, the stone was removed, and sent to the pathology lab. The patient was discharged 24 h later in good general condition. According to the pathology report, the components of the stone were identified as calcium oxalate.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"6658363"},"PeriodicalIF":0.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calvarial Chondroplastic Osteosarcoma With Distant Brain Metastasis Treated With Radiosurgery: A Rare Case Report.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.1155/carm/5412921
Mohammed A Azab, Ahmed Hazim, Nour El-Gohary, Mohsen Nabih Shama, Brahim Kammoun

Background: Cerebral metastases from soft tissue and bone sarcoma are uncommon. Metastatic sarcoma of the brain is a highly aggressive disease with a poor prognosis. There is no consensus regarding the management of cerebral metastases from bone sarcomas. Clinical Presentation: The patient is a 60-year-old, right-handed male, who presented with a right frontal scalp swelling that was hard in consistency. On examination, he had pain and tenderness over the swelling. The neurological examination was normal. Investigations: Initial CTH revealed a right frontal skull lesion with characteristic expansion and sunburst appearance with a degree of cortical destruction. MRI brain with contrast showed features suggestive of skull osteosarcoma. Management: He underwent a subtotal tumor resection. He was diagnosed with high-grade chondroblastoma-like osteosarcoma of the skull. Subsequently, he received three cycles of neoadjuvant chemotherapy in the form of Adriamycin and cisplatin. One year later, he underwent further surgical intervention with an additional skull resection and reconstruction using mesh and scalp reconstruction. Follow-Up: MRI brain with contrast showed a distant metastasis in the right transverse sinus and other distant brain areas and were treated with Gamma Knife radiosurgery (GKRS) 6 months after the primary surgery. Conclusion: Skull calvarium primary osteosarcoma is a rare pathology. Cerebral metastasis from skull bone osteosarcoma is a challenging clinical situation that requires a multidisciplinary therapeutic approach that includes neurosurgery, plastic surgery, chemotherapy, and radiosurgery.

{"title":"Calvarial Chondroplastic Osteosarcoma With Distant Brain Metastasis Treated With Radiosurgery: A Rare Case Report.","authors":"Mohammed A Azab, Ahmed Hazim, Nour El-Gohary, Mohsen Nabih Shama, Brahim Kammoun","doi":"10.1155/carm/5412921","DOIUrl":"10.1155/carm/5412921","url":null,"abstract":"<p><p><b>Background:</b> Cerebral metastases from soft tissue and bone sarcoma are uncommon. Metastatic sarcoma of the brain is a highly aggressive disease with a poor prognosis. There is no consensus regarding the management of cerebral metastases from bone sarcomas. <b>Clinical Presentation:</b> The patient is a 60-year-old, right-handed male, who presented with a right frontal scalp swelling that was hard in consistency. On examination, he had pain and tenderness over the swelling. The neurological examination was normal. <b>Investigations:</b> Initial CTH revealed a right frontal skull lesion with characteristic expansion and sunburst appearance with a degree of cortical destruction. MRI brain with contrast showed features suggestive of skull osteosarcoma. <b>Management:</b> He underwent a subtotal tumor resection. He was diagnosed with high-grade chondroblastoma-like osteosarcoma of the skull. Subsequently, he received three cycles of neoadjuvant chemotherapy in the form of Adriamycin and cisplatin. One year later, he underwent further surgical intervention with an additional skull resection and reconstruction using mesh and scalp reconstruction. <b>Follow-Up:</b> MRI brain with contrast showed a distant metastasis in the right transverse sinus and other distant brain areas and were treated with Gamma Knife radiosurgery (GKRS) 6 months after the primary surgery. <b>Conclusion:</b> Skull calvarium primary osteosarcoma is a rare pathology. Cerebral metastasis from skull bone osteosarcoma is a challenging clinical situation that requires a multidisciplinary therapeutic approach that includes neurosurgery, plastic surgery, chemotherapy, and radiosurgery.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"5412921"},"PeriodicalIF":0.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Infantile Reversible Cytochrome C Oxidase Deficiency Myopathy in Taiwan: A 4-Year Follow-Up.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.1155/carm/1823517
Yu-Ting Ma, Ju-Li Lin, Ming-Wei Lai, I-Jun Chou, Mao-Sheng Hwang

Infantile reversible cytochrome c oxidase (COX) deficiency myopathy is a mitochondrial rare disease with onset age of first day to three months with symptoms of generalized muscle weakness and severe hypotonia. Despite its initial serious conditions, the symptoms may improve spontaneously later in their life, with the so-called "benign" myopathy accordingly. This benign mitochondrial myopathy might be improved in their later life, which is different from most mitochondrial myopathies with progression by age. Therefore, we depicted the rare case of her clinical course during our medical practice, anticipating to provide more information of this rare disease.

{"title":"A Case of Infantile Reversible Cytochrome C Oxidase Deficiency Myopathy in Taiwan: A 4-Year Follow-Up.","authors":"Yu-Ting Ma, Ju-Li Lin, Ming-Wei Lai, I-Jun Chou, Mao-Sheng Hwang","doi":"10.1155/carm/1823517","DOIUrl":"10.1155/carm/1823517","url":null,"abstract":"<p><p>Infantile reversible cytochrome c oxidase (COX) deficiency myopathy is a mitochondrial rare disease with onset age of first day to three months with symptoms of generalized muscle weakness and severe hypotonia. Despite its initial serious conditions, the symptoms may improve spontaneously later in their life, with the so-called \"benign\" myopathy accordingly. This benign mitochondrial myopathy might be improved in their later life, which is different from most mitochondrial myopathies with progression by age. Therefore, we depicted the rare case of her clinical course during our medical practice, anticipating to provide more information of this rare disease.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"1823517"},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arrhythmia as a Possible Complication of Mycophenolate Mofetil in Systemic Sclerosis: A Case Report.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI: 10.1155/carm/8858671
Zahra Moradi, Vahid Ardestani, Zahra Tamartash, Elaheh Karimi, Hoda Kavosi

A 55-year-old male patient with diffuse cutaneous systemic sclerosis (dcSSC) since 2018 presented with a history of arrhythmia. He had been stable for 5 years with pantoprazole, diltiazem, and mycophenolate mofetil (MMF); vitamin E; and vitamin D until he developed arrhythmia. Different evaluations revealed left bundle branch block, wall motion abnormality, mildly reduced systolic function, diffused interstitial fibrosis, and lesions in the left circumflex artery (LCX) and left anterior descending artery (LAD) and stenosis in LCX, without significant improvement following percutaneous coronary intervention for LCX stenosis. Holter monitoring demonstrated persistent ventricular premature beats and couplets. Arrhythmia was not responsive to bisoprolol therapy, and it was not feasible to perform cardiac ablation. Suspecting MMF-induced arrhythmia, MMF was discontinued, which led to a reduction in arrhythmia and symptom improvement after 9 months. This case report emphasized a possible heart-related complication of MMF, which healthcare providers should consider when prescribing medication to patients.

{"title":"Arrhythmia as a Possible Complication of Mycophenolate Mofetil in Systemic Sclerosis: A Case Report.","authors":"Zahra Moradi, Vahid Ardestani, Zahra Tamartash, Elaheh Karimi, Hoda Kavosi","doi":"10.1155/carm/8858671","DOIUrl":"10.1155/carm/8858671","url":null,"abstract":"<p><p>A 55-year-old male patient with diffuse cutaneous systemic sclerosis (dcSSC) since 2018 presented with a history of arrhythmia. He had been stable for 5 years with pantoprazole, diltiazem, and mycophenolate mofetil (MMF); vitamin E; and vitamin D until he developed arrhythmia. Different evaluations revealed left bundle branch block, wall motion abnormality, mildly reduced systolic function, diffused interstitial fibrosis, and lesions in the left circumflex artery (LCX) and left anterior descending artery (LAD) and stenosis in LCX, without significant improvement following percutaneous coronary intervention for LCX stenosis. Holter monitoring demonstrated persistent ventricular premature beats and couplets. Arrhythmia was not responsive to bisoprolol therapy, and it was not feasible to perform cardiac ablation. Suspecting MMF-induced arrhythmia, MMF was discontinued, which led to a reduction in arrhythmia and symptom improvement after 9 months. This case report emphasized a possible heart-related complication of MMF, which healthcare providers should consider when prescribing medication to patients.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"8858671"},"PeriodicalIF":0.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not Every Headache Warrants a Head CT: A Recurrent Headache Unveiling H. Pylori-Positive MALToma.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.1155/carm/1773577
Rebal Nahas, Serena Khoury, Emanuel-Youssef Dib, Karam Karam, Elias Fiani

Helicobacter pylori (H. pylori) is a urease-producing bacterium that has a tendency to colonize the gastric mucosa. H. pylori can cause atrophic gastritis and gastric intestinal metaplasia (GIM). H. pylori has also been associated with MALT lymphoma, which is an extranodal marginal zone lymphoma. The gold standard for the diagnosis of H. pylori is histopathological analysis from biopsied gastric mucosa. MALT lymhoma can have a wide range of clinical manifestations, such as epigastric pain, iron-deficiency anemia, and overt upper gastrointestinal (GI) bleeding. MALT lymphoma has been rarely associated with headaches. We describe a case of H. pylori-positive MALToma manifesting as epigastric pain occurring concomitantly with throbbing headaches; hence, headache can be a heralding symptom for the diagnosis of MALToma.

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引用次数: 0
Iliopsoas Abscess Heralding the Diagnosis of Crohn's Disease in a Young Male.
IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-08 eCollection Date: 2025-01-01 DOI: 10.1155/carm/5555016
Majed Ali, Karam Karam, Emanuel-Youssef Dib, Lamia Azizi, Elias Fiani

Iliopsoas abscess (IPA) is a rare but potentially life-threatening complication that may occur in patients with Crohn's disease. We present the case of a 28-year-old male with Crohn's disease who developed a complicated IPA. Diagnosis was confirmed via CT imaging and colonoscopy, revealing a fistulous connection to the terminal ileum. The treatment involved percutaneous drainage (PCD), antibiotics, and infliximab. Timely diagnosis, appropriate imaging, and multidisciplinary care are critical to prevent morbidity and recurrence in patients with Crohn's disease complicated by IPA. This case highlights the importance of personalized treatment strategies and close follow-up in managing Crohn's-related IPA.

{"title":"Iliopsoas Abscess Heralding the Diagnosis of Crohn's Disease in a Young Male.","authors":"Majed Ali, Karam Karam, Emanuel-Youssef Dib, Lamia Azizi, Elias Fiani","doi":"10.1155/carm/5555016","DOIUrl":"10.1155/carm/5555016","url":null,"abstract":"<p><p>Iliopsoas abscess (IPA) is a rare but potentially life-threatening complication that may occur in patients with Crohn's disease. We present the case of a 28-year-old male with Crohn's disease who developed a complicated IPA. Diagnosis was confirmed via CT imaging and colonoscopy, revealing a fistulous connection to the terminal ileum. The treatment involved percutaneous drainage (PCD), antibiotics, and infliximab. Timely diagnosis, appropriate imaging, and multidisciplinary care are critical to prevent morbidity and recurrence in patients with Crohn's disease complicated by IPA. This case highlights the importance of personalized treatment strategies and close follow-up in managing Crohn's-related IPA.</p>","PeriodicalId":9627,"journal":{"name":"Case Reports in Medicine","volume":"2025 ","pages":"5555016"},"PeriodicalIF":0.8,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Case Reports in Medicine
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