Design and biological activity of a novel fungicide, quinofumelin.

IF 1.5 4区 农林科学 Q2 ENTOMOLOGY Journal of Pesticide Science Pub Date : 2023-02-20 DOI:10.1584/jpestics.D22-042
Hiroyuki Ito, Takeshi Takada, Munetsugu Morimoto, Hiroyuki Komai, Fumie Kajino, Toshiaki Ohara, Yasushi Tamagawa, Mikio Tsuda, Shinichi Banba
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Abstract

Developed by Mitsui Chemicals Agro, Inc. (Tokyo, Japan), quinofumelin is a novel fungicide with a distinct chemical structure including 3-(isoquinolin-1-yl) quinoline, demonstrating fungicidal activity against a variety of fungi, including rice blast and gray mold. We screened our compound library to identify curative compounds for rice blast and evaluated the effect of fungicide-resistant strains of gray mold. Our research demonstrated that quinofumelin has curative effects against rice blast and is not cross-resistant to existing fungicides. Accordingly, the use of quinofumelin can be considered a novel approach for disease control in agricultural production. In this report, the discovery of quinofumelin from the initial compound is described in detail.

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新型杀菌剂喹诺芬林的设计及生物活性研究。
quinofumelin是由日本三井化学农业公司(Tokyo, Japan)开发的一种新型杀菌剂,具有独特的化学结构,包括3-(异喹啉-1-基)喹啉,对多种真菌(包括稻瘟菌和灰霉病)具有杀真菌活性。筛选化合物文库,鉴定稻瘟病治疗化合物,并评价灰霉抗杀菌剂菌株的效果。我们的研究表明,喹诺菲林对稻瘟病菌有治疗效果,而且对现有的杀菌剂没有交叉抗性。因此,喹诺菲林的使用可被认为是农业生产中疾病控制的一种新方法。在这篇报告中,详细描述了从最初的化合物中发现喹诺菲林的过程。
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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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