Integrative analysis of gene and protein expression in atherosclerosis-related pathways modulated by periodontal pathogens. Systematic review

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2023-01-09 DOI:10.1016/j.jdsr.2022.12.001

Talia Yolanda Marroquin , Sandra Guauque-Olarte

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引用次数: 1

Abstract

The mechanisms modulated by periodontal pathogens in atherosclerosis are not fully understood. Aim: to perform an integrative analysis of gene and protein expression modulated by periodontal pathogens in cells and animal models for atherosclerosis.

Methods

Cochrane, PRISMA and AMSTAR2 guidelines for systematic reviews were followed. Data search was conducted in Pub-med, LILACS and Science Direct databases. Gene and protein expression data were collected from the included papers to perform an overrepresentation analysis using the Reactome Pathway Analysis tool and the KEGG database.

Results

Thirty-two papers were included in the review, they analyzed the effect of Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus anginosus, Streptococcus sanguinis, Tannerella forsythia, and Treponema denticola or/and their virulent factors on gene and protein expression in human cells and animal models of atherosclerosis. Some of the modulated pathways include the immune system, programmed cell death, cellular responses to external stimuli, transport of small molecules, and signal transduction (p < 0.05). Those pathways are known to be involved in different stages of atherosclerosis progression.

Conclusion

Based on the performed analysis, it is possible to state that periodontal pathogens have the potential to be a contributing factor for atherosclerosis even in absence of a high-fat diet or high shear stress.

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牙周病原体调控动脉粥样硬化相关通路基因和蛋白表达的综合分析。系统综述

牙周病原体在动脉粥样硬化中调节的机制尚不完全清楚。目的：对牙周病原体在动脉粥样硬化细胞和动物模型中调节的基因和蛋白质表达进行综合分析。方法遵循Cochrane、PRISMA和AMSTAR2系统评价指南。数据检索在Pub-med、LILACS和Science Direct数据库中进行。从纳入的论文中收集基因和蛋白质表达数据，使用Reactome Pathway analysis工具和KEGG数据库进行过度表达分析。结果共收录32篇论文，分析了有核梭杆菌、牙龈卟啉单胞菌、血管链球菌、血链球菌、连翘单胞菌和齿密螺旋体或/或其毒力因子对人细胞和动脉粥样硬化动物模型中基因和蛋白质表达的影响。一些被调节的途径包括免疫系统、程序性细胞死亡、细胞对外部刺激的反应、小分子的转运和信号转导（p<；0.05）。已知这些途径参与动脉粥样硬化进展的不同阶段。结论根据所进行的分析，即使在没有高脂肪饮食或高剪切应力的情况下，牙周病原体也有可能成为动脉粥样硬化的促成因素。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.