The effect of ginger (Zingiber officinale) extract on the neutrophil level and CAT (COPD Assessment Test) scores in workers with COPD due to dust exposure

Susilo Budi Pratama, Y. Setyaningsih, Daru Lestyanto
{"title":"The effect of ginger (Zingiber officinale) extract on the neutrophil level and CAT (COPD Assessment Test) scores in workers with COPD due to dust exposure","authors":"Susilo Budi Pratama, Y. Setyaningsih, Daru Lestyanto","doi":"10.30651/jqm.v6i1.9711","DOIUrl":null,"url":null,"abstract":"ABSTRACT  Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure. Keywords             : COPD, CAT score, neutrophil, gingerCorrespondence   : susilobudipratama@gmail.com ","PeriodicalId":31682,"journal":{"name":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","volume":"96 2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Qanun Medika Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30651/jqm.v6i1.9711","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

ABSTRACT  Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airflow limitation that does not fully return to normal and is associated with the increased inflammatory response in the airways due to exposure to noxious particles or gases. Workers are susceptible to exposure to steam, dust, gases, and fumes in the work environment. Administration of antioxidants can be beneficial in COPD patients by reducing oxidative stress to reduce the inflammatory response. Ginger contains various active ingredients that act as antioxidants. The research design is a quasi-experimental study with a pre-test and post-test approach. The research subjects were 30 subjects workers diagnosed with COPD. Subjects were divided into two groups: the control group was given standard therapy, the treatment group was given standard therapy and ginger extract. The treatment was given for one month, then the neutrophil and the COPD Assessment Test (CAT) scores were checked. The data were analyzed with an unpaired difference test. The treatment group (-5.67 +2.32) experienced more CAT decline than the control group (-0.73 +1.28) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = <0.001). The treatment group (-4.93 +4.43) experienced more neutrophil decline than the control group (0.27 +1.10) and showed a significant difference; this was evidenced in the unpaired difference test on the post-pre difference value (p = < 0.001). Administration of ginger extract can reduce neutrophil levels and CAT scores in COPD workers due to dust exposure. Keywords             : COPD, CAT score, neutrophil, gingerCorrespondence   : susilobudipratama@gmail.com 
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
姜(Zingiber officinale)提取物对粉尘暴露COPD工人中性粒细胞水平和CAT (COPD评估测试)评分的影响
慢性阻塞性肺疾病(COPD)是一种进行性疾病,其特征是气流受限,不能完全恢复正常,并且与暴露于有毒颗粒或气体导致气道炎症反应增加有关。工人在工作环境中容易接触蒸汽、灰尘、气体和烟雾。抗氧化剂的管理可以通过减少氧化应激减少炎症反应对COPD患者有益。生姜含有多种抗氧化剂的活性成分。本研究设计为准实验研究,采用前测与后测相结合的方法。研究对象是30名被诊断患有慢性阻塞性肺病的工人。将受试者分为两组:对照组给予标准治疗,治疗组给予标准治疗和生姜提取物。治疗1个月后,观察中性粒细胞和慢性阻塞性肺病评估试验(COPD Assessment Test, CAT)评分。数据采用非配对差异检验进行分析。治疗组CAT下降幅度(-5.67 +2.32)大于对照组(-0.73 +1.28),差异有统计学意义;这在前后差异值的未配对差异检验中得到了证明(p = <0.001)。治疗组中性粒细胞下降(-4.93 +4.43)明显高于对照组(0.27 +1.10),差异有统计学意义;这在前后差异值的未配对差异检验中得到了证明(p = < 0.001)。生姜提取物的管理可以降低中性粒细胞水平和CAT评分的COPD工人由于粉尘暴露。关键词:COPD, CAT评分,中性粒细胞,姜对应:susilobudipratama@gmail.com
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
32
审稿时长
8 weeks
期刊最新文献
An Unusual Laryngeal Foreign Body in Adult: Denture CRISPR-Cas9 through AAV delivery system as a gene therapy in Parkinson’s disease An overview of anxiety levels of Muhammadiyah citizens against COVID-19 vaccination in Surabaya Relationship of genetic factors to the degree of Acne vulgaris as one of the predisposing factors in student Faculty of Medicine University of Muhammadiyah Malang Seroprevalence of Galactomannan Aspergillus in COVID-19 patients in Jakarta: A challenge in the pandemic commotion
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1