Retinal layers and symptoms and inflammation in schizophrenia.

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2024-08-01 Epub Date: 2023-03-16 DOI:10.1007/s00406-023-01583-0
Marcelo Alves Carriello, Diogo F Bornancin Costa, Pedro Henrique Pereira Alvim, Mariana Camargo Pestana, Duana Dos Santos Bicudo, Eloisa Maria Pontarolo Gomes, Tamires Amelotti Coelho, Patrick Junior Biava, Vitória Gabriela Berlitz, Ana J Bianchini, Aline Shiokawa, Naoye Shiokawa, Mario Teruo Sato, Raffael Massuda
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Abstract

Schizophrenia is a neurodevelopmental disorder that affects brain structure and function. The retina, as well as the brain, consists of neuronal and glial cells packed in layers. Cortical volume and brain thickness are associated with inflammatory biomarkers, however, no study has been performed associating inflammatory biomarkers and retina in schizophrenia. our study aims to compare the retinal macular thickness and volume and peripapillary thickness in patients with schizophrenia and controls, and associate it to symptoms of schizophrenia, to interleukin-6 (IL-6) and C Reactive Protein (CRP) levels. Optical coherence tomography was performed to assess retinal layer thickness and volume, and CRP and IL-6 levels were measured in patients with schizophrenia and controls. Positive, negative, and general symptoms of schizophrenia were measured with the Positive and Negative Syndrome Scale (PANSS). A linear regression controlling for confounding factors was performed. 70 subjects were included, 35 patients, and 35 controls matched for sex and age. Patients with schizophrenia presented a significantly lower macular volume (p < 0.05) and thickness (< 0.05) than controls. PANSS positive, general and total scores were associated with retinal nerve fiber layer (RNFL) thickness (p < 0.05). There was no association between inflammatory markers (CRP and IL-6) levels and the retinal layer. A reduction in macular volume and thickness was found in patients with schizophrenia. The severity of schizophrenia symptoms was associated with RNFL thickness. CRP and IL-6 are not associated with retinal thickness/volume in schizophrenia or controls.

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精神分裂症的视网膜层、症状和炎症。
精神分裂症是一种影响大脑结构和功能的神经发育障碍。视网膜和大脑一样,由神经元细胞和神经胶质细胞组成。我们的研究旨在比较精神分裂症患者和对照组的视网膜黄斑厚度、体积和毛周厚度,并将其与精神分裂症症状、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平联系起来。对精神分裂症患者和对照组进行了光学相干断层扫描,以评估视网膜层厚度和体积,并测量了 CRP 和 IL-6 水平。精神分裂症的阳性、阴性和一般症状采用阳性和阴性综合征量表(PANSS)进行测量。对混杂因素进行了线性回归。共纳入了 70 名受试者,其中 35 人为患者,35 人为性别和年龄匹配的对照组。精神分裂症患者的黄斑体积明显较小(p
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
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