Genetic screening in gamete donation: Recommendations from SEF, ASESA, AEBM-ML, ASEBIR and AEGH

Medicina Reproductiva y Embriología Clínica Pub Date : 2020-01-01 DOI:10.1016/j.medre.2020.02.001

Jose A. Castilla , Fernando Abellán , Pilar Alamá , Mónica Aura , Lluís Bassas , Eli Clúa , Alfonso De la Fuente , Juanjo Guillén , Dolors Manau , Joaquin Rueda , Miguel Ruiz , Xavier Vendrell , on behalf of the Spanish Fertility Society, the Spanish Association of Andrology, the Spanish Association of Medical Biopathology and Laboratory Medicine, the Association for the Study of Reproductive Biology, the Spanish Association of Human Genetics

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引用次数: 3

Abstract

Recommendations are made for the genetic screening of gamete donors. These recommendations are the result of the consensus reached by a work group consisting of representatives from the Spanish Fertility Society, the Spanish Association of Andrology, the Spanish Association of Medical Biopathology and Laboratory Medicine, the Association for the Study of Reproductive Biology and the Spanish Association of Human Genetics and were subsequently reviewed and approved by the executive boards of each of these associations. This document describes 2 types of genetic screening: a basic mandatory screening of all donors and an extended genetic screening for donor-recipient genetic matching. The importance of pre- and post-screening genetic counselling, the management of the occurrence of adverse reactions of a genetic nature and the use of informed consent from donors who accept the management of their DNA samples stored in the centre's bank are emphasized. The role of informed consent to find out patients’ opinions on what type of screening they want to be carried out, their desire to know the results of the screening and aptitude for future genetic data is also highlighted.

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配子捐献的遗传筛查:来自SEF, ASESA, AEBM-ML, ASEBIR和AEGH的建议

建议配子供体的遗传筛选。这些建议是由西班牙生育学会、西班牙男科学会、西班牙医学生物病理学和实验室医学协会、生殖生物学研究协会和西班牙人类遗传学协会的代表组成的工作组达成共识的结果，随后由这些协会的执行局进行了审查和批准。本文件描述了2种类型的遗传筛查:对所有供体的基本强制性筛查和对供体-受体基因匹配的扩展遗传筛查。强调了筛查前和筛查后的遗传咨询的重要性，对遗传性质不良反应发生的管理，以及使用接受管理其存储在中心银行中的DNA样本的捐助者的知情同意。知情同意的作用是了解患者对他们想要进行哪种类型的筛查的意见，他们想知道筛查结果的愿望以及未来遗传数据的能力。

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Medicina Reproductiva y Embriología Clínica

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