Alterations in Levels of Oxidative Stress Biomarkers, Some Serum Interleukins and Hormones in Infertile Women

Abstract

The aim of this study was to evaluate the effect of oxidative stress and someserum interleukins and hormones levels of women with primary infertility, and toreveal the correlation between them.A total of 120 infertile women with different etiologies and 45 fertile women as acontrol were investigated, their age ranged between (16-45) years old. The levels of serum TAC, SOD activity, GSH, MDA, Mg, Zn, catalase activity, interleukin-1β and interleukin- 8 were estimated, also the levels of LH, FSH, prolactin, progesterone, AMH, inhibin B and leptin were estimated.The current results were revealed that there was a significant elevation in thelevels of MDA, interleukin- 1β, prolactin and leptin, and a significant decrease inTAC, SOD, GSH, Mg, Zn, catalase activity, AMH and inhibin B between theinfertile and fertile groups. There was a positive correlation between SOD withAMH, inhibin B and Mg, and positive correlation between LH and FSH, TAC andinhibin B. there was a negative correlation between FSH and inhibinB. In conclusion, it suggested that inhibin B may play a role in theantioxidant–oxidant balance.