A comparative study of clonidine versus dexmedetomidine in attenuation of stress response to laryngoscopy and intubation

Abstract

Background: Endotracheal intubation produces various cardio vascular complications. Sometimes these complications lead to mortality. Various anaesthetic drugs are tried before intubation to reduce the haemodynamic changes. The present study aimed to evaluate the clonidine versus dexmedetomidine in attenuation of stress response to laryngoscopy and intubation. Materials and Methods: The study was done in Department of Anaesthesia , Sree Gokulam Medical College and Research Foundation, Trivandrum, Kerala. A total of 50 patients included in the study based on the inclusion and exclusion criteria and divided into two group each of 25. G-I received Clonidine (2mcg/kg) and G-II Dexmedetomidine (0.5mcg/kg). Drugs are given to respective groups 10 min before induction. Demographic data (age and gender) and clinical data (heart rate, SBP, DBP and MAP) was recorded. SPSS (20.0) version was used for analysis. Results: Group-I and II not showed any significant difference on comparison of demographic data. Comparison of mean heart rate between the group-I and II not showed any significant difference. SBP (PI, AL), DBP (PI) and MAP (PI) showed significant difference when compared between the group-I and II. Conclusion: Dexmedetomidine in the dose of 0.5µg/kg, given 10 minutes before laryngoscopy and intubation is better choice than clonidine in attenuating the haemodynamic responses to laryngoscopy and intubation.