{"title":"Diabetic Ocular Complications in the SDT Rat","authors":"A. Kakehashi","doi":"10.2174/1876524601104010037","DOIUrl":null,"url":null,"abstract":"The purpose of the current article was to describe the diabetic ocular complications in a new animal model of diabetes, the Spontaneously Diabetic Torii (SDT) rat. Three major diabetic ocular complications, cataract, diabetic retinopathy (DR), and neovascular glaucoma develop in the SDT rat. The cataract develops to maturity, and DR develops to the advanced stage. Large retinal folds mimicking a tractional retinal detachment with extensive fluorescein leakage around the optic disc are the most characteristic finding of DR in this rat. In some rats, neovascular glaucoma develops with a massive hemorrhage in the anterior chamber associated with neovascular fibrous membranes around the iris. Although there are some differences in the diabetic ocular complications between SDT rats and human patients with diabetes, the SDT rat model is useful for studying diabetic ocular complications.","PeriodicalId":22762,"journal":{"name":"The Open Diabetes Journal","volume":"21 1","pages":"37-40"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Diabetes Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876524601104010037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The purpose of the current article was to describe the diabetic ocular complications in a new animal model of diabetes, the Spontaneously Diabetic Torii (SDT) rat. Three major diabetic ocular complications, cataract, diabetic retinopathy (DR), and neovascular glaucoma develop in the SDT rat. The cataract develops to maturity, and DR develops to the advanced stage. Large retinal folds mimicking a tractional retinal detachment with extensive fluorescein leakage around the optic disc are the most characteristic finding of DR in this rat. In some rats, neovascular glaucoma develops with a massive hemorrhage in the anterior chamber associated with neovascular fibrous membranes around the iris. Although there are some differences in the diabetic ocular complications between SDT rats and human patients with diabetes, the SDT rat model is useful for studying diabetic ocular complications.
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