Renal Toxicity Induced by Carbon Tetrachloride in Experimental Model

Abstract

Carbon tetrachloride (CCl4) is largely used as a solvent in chemical industries. It is also well known for hepatic and renal toxic actions. It imposes serious health threats. It is also one of the major causes that is toxic for the vital organs like lungs, kidney, liver, brain, etc. Objective: To check nephrotoxicity of Carbon Tetrachloride (CCl4) on Rat Kidneys. Methods: The experiment was conducted at the animal house of the Department of Zoology, University of Okara. The targeted animal was Albino Rat. Two groups were designed control and experimental groups. The rats were fed with 30% diluted CCl4 to check the toxic effect on the kidneys and normal saline to the control group for comparison. A trial for 12 days was conducted for this purpose. Sampling or dissection was done after 12 days to determine serum Urea, Creatinine, and Electrolytes Sodium (Na), and Potassium (K). Rats were dissected and the heart was punctured to take a blood sample and to collect organs. Results: We observed the increased values of Urea, Creatinine and Electrolytes, Sodium (Na), and Potassium (K) as compared to normal values, which have proved the renal toxicity was induced by CCl4 in Albino Rats. All the experimental data were analyzed by using SPSS-19. The level of significance among the various treatments was determined by LSD at a 0.05% level of probability. Conclusions: These findings underline the substantial health risks that CCl4 poses and emphasize the necessity of putting preventative measures and safety regulations in place.