Heterogeneous Catalytic Method for the One-pot Three-component Synthesis of Isoquinolonic Acid Derivatives Catalyzed by a 4Å Molecular Sieves Supported Lanthanum Catalyst

Abstract

Lanthanum supported on 4Å molecular sieves proved to be an efficient heterogeneous catalyst for the one-pot three-component synthesis of 1,2,3,4-tetrahydroisoquinolinone-4-carboxylic acid derivatives from homophthalic anhydride, aromatic aldehydes and an amine component, ammonium acetate or aralkyl amines, with good to excellent yields. The catalyst could be recovered easily and reused without significant loss of its initial activity.