Antibacterial and Antifungal Activity Essay of Alkaloids Extracted from Four Combretaceae Used in Senegal

Abstract

The use of medicinal plants remains important in West Africa where Combretaceae are among the most widely used for the treatment and herbal teas. The objective of this study is to extract total alkaloids from four plants of the Combretaceae family and test their antibacterial and antifungal activities. The results of the extraction showed that Combretum glutinosum is the richest with 0.61% in alkaloids. It is followed by Anogeissus leiocarpus, 0.13%. The study of antimicrobial activity has globally shown that alkaloids are more active against fungi than against bacteria. In this study, the lowest MIC, 93µg/ml, was obtained with alkaloids from Guiera senegalensis against Staphylococcus aureus. On the other hand, the total alkaloids extracted from Combretum glutinosum are the only ones that are active against all strains, both bacterial and fungal.