{"title":"Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications","authors":"Sankha Bhattacharya","doi":"10.2174/2213476x07666200827102951","DOIUrl":null,"url":null,"abstract":"\n\nPoor aqueous solubility, oral bioavailability, inter, and inter-subject\nvariability, and physical stability have always been a concern for pharmaceutical\nformulation scientists while formulating an oral dosage form. Self-Emulsifying\nDrug Delivery System (SEDDS) is a promising new approach to mitigating those\npotential problems. The main advantages of SEDDS are that it increases the solubility\nand decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV\nClass drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents,\nand stabilizers. With little energy input, they form (o/w) microemulsion\nwithin the G.I. lumen. The present review discusses the various formulations of\nSEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms,\nsolidification technique, characterization, and future approaches.\n","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"43 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213476x07666200827102951","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Poor aqueous solubility, oral bioavailability, inter, and inter-subject
variability, and physical stability have always been a concern for pharmaceutical
formulation scientists while formulating an oral dosage form. Self-Emulsifying
Drug Delivery System (SEDDS) is a promising new approach to mitigating those
potential problems. The main advantages of SEDDS are that it increases the solubility
and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV
Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents,
and stabilizers. With little energy input, they form (o/w) microemulsion
within the G.I. lumen. The present review discusses the various formulations of
SEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms,
solidification technique, characterization, and future approaches.
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