Fungicidal Mechanism of Ortho-Phthaldialdehyde-benzyldlmethyldodecylammonlum Chloride as A Disinfectant Against Candida Albicans

Abstract

Candida albicans is a common fungal pathogen, which is resistant to most commonly used disinfectants. It can cause serious interference in more than ten countries and even lead to death, so it is considered to be a serious global health threat. Obviously, in order to effectively control the spread of Candida albicans, the development of an efficient disinfectant is an important strategy. In this research, the fungicidal mechanism of ODB for Candida albicans was investigated through membrane fluidity, membrane integrity, protein leakage, functional changes of cell and mitochondria. ODB can affect fluidity and integrity of the cell membrane of Candida albicans, result in large amount of ions, proteins, glycerol, reactive oxygen species, ATP and DNA to leak, lower or dysfunction mitochondria by deteriorating cell ability to produce ATP or to make use of ATP, and less DNA content. And all these changes in structure and function are the main causes of the ultimate death of Candida albicans.