Basappa, D. Rangappa, K. Thanuja, K. Rangappa, M. Rani, T. Swaroop
{"title":"Synthesis, Characterization and Cytotoxic Studies of Benzamide Derivatives of Anacardic Acid using Human Liver Cancer Cells","authors":"Basappa, D. Rangappa, K. Thanuja, K. Rangappa, M. Rani, T. Swaroop","doi":"10.31487/j.cor.2020.04.07","DOIUrl":null,"url":null,"abstract":"Naturally occurring anacardic acid based benzamides were reported to show anti-inflammatory and\nanticancer activities, where we synthesized and characterized by NMR and HRMS analysis and also tested\na series of anacardic acid based benzamides and evaluated against the proliferation of human liver cancer\ncells (HepG2). Among the tested compounds, 6j-m showed good inhibitory activity against HepG2 cells\nwith IC50 values ranging from 78.2-91.9 μM. In conclusion, we herein reported the newer series of an\nacademic acid benzamides for the first time.","PeriodicalId":10487,"journal":{"name":"Clinical Oncology and Research","volume":"47 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oncology and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31487/j.cor.2020.04.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Naturally occurring anacardic acid based benzamides were reported to show anti-inflammatory and
anticancer activities, where we synthesized and characterized by NMR and HRMS analysis and also tested
a series of anacardic acid based benzamides and evaluated against the proliferation of human liver cancer
cells (HepG2). Among the tested compounds, 6j-m showed good inhibitory activity against HepG2 cells
with IC50 values ranging from 78.2-91.9 μM. In conclusion, we herein reported the newer series of an
academic acid benzamides for the first time.
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