DRUG UTILIZATION EVALUATION OF ANTI-EPILEPTICS IN A TERTIARY CARE TEACHING HOSPITAL

Abstract

Neurological diseases are gaining more importance in the developing countries like India in recent times. Epilepsy is one of the most important neurological disorders. It describes a condition in which a person experience recurrent seizures due to a chronic, underlying process. A Prospective Observational study was carried out at Rajiv Gandhi Institute of Medical Sciences, Kadapa. A total of 65 patients were selected in a 6 months period based upon the inclusion and exclusion criteria. In the present study we made an attempt to conduct Drug utilization evaluation (DUE) in epileptic patients to improve treatment rationality in a tertiary care teaching hospital. Demographic and prescription data was collected and assessed based upon the DUE. From that we found that generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Our data suggests that unknown cause and stress is main offender of symptomatic epilepsy. Furthermore, we observed that there was some inappropriate usage of Anti-epileptic drugs which comprises drug-drug interaction and incorrect dosage regimen. we found generalized seizures were the most prominent seizure encountered and monotherapy was the most frequently used treatment in all types of epileptic seizures. Most commonly prescribed drug was Phenytoin. We found ADRs, medication errors and drug interactions in World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 453-469. Research Article ISSN 2277– 7105 Article Received on 01 August 2017, Revised on 22 August 2017, Accepted on 12 Sept. 2017 DOI: 10.20959/wjpr201711-9272