Efficacy of autologous platelet-rich plasma for long-term glucocorticoids caused chronic wound: a case report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-01 Epub Date: 2023-03-10 DOI:10.1007/s10561-023-10083-3

Ziang Zhang, Jie Long, Jian Geng, Wensen Xia

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Abstract

The repair of bone explore wounds is one of the difficult problems in plastic and reconstruction surgery. Platelet-rich plasma (PRP) is a safe and efficient therapeutic option for various trauma, including Osteoarticular, musculoskeletal, and Wound injuries. However, the preparation and storage of PRP becomes challenging for patients with poor systemic status and requiring multi-use of PRP. The availability of safe, reliable tissue bank makes it possible. We report a case of a 42-year-old woman patient with a chronic hip wound combined with ischium bone exploration. And the patient who was treated with long-term glucocorticoids for rheumatoid arthritis has been through the experience of extensive conservative management. Thereafter necrosectomy and Vacuum-Assisted Closure (VAC) surgical procedure failed, and a PRP daily injection was performed at the ischial muscle and soft tissue. Neo-muscle appeared around the explored ischium bone after 8 weeks of injection and Complete wound healing was obtained in 3 months.

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自体富血小板血浆治疗长期糖皮质激素所致慢性创伤的疗效：一例报告。

骨探索性创伤的修复是整形外科和重建外科的难题之一。富含血小板血浆（PRP）是一种安全有效的治疗各种创伤的选择，包括骨关节、肌肉骨骼和创伤。然而，PRP的制备和储存对于全身状况不佳且需要多次使用PRP的患者来说变得具有挑战性。安全可靠的纸巾库使之成为可能。我们报告了一例42岁的女性患者，她患有慢性髋关节创伤并伴有坐骨探查。长期使用糖皮质激素治疗类风湿性关节炎的患者经历了广泛的保守治疗。此后，坏死切除术和真空辅助闭合术（VAC）手术失败，每天在坐骨肌和软组织注射PRP。注射8周后，坐骨周围出现新生肌肉，3个月内伤口完全愈合。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.