Bioactive compounds in Magnifera indica demonstrates dose-dependent anti- inflammatory effects

Abstract

Magnifera indica (MI) is one of the notable medicinal plants use for the treatment of inflammatory diseases in folkloric medicine. Recent studies by present author demonstrated anti-inflammatory effects of Mangifera indica to have dose-dependent effects, pointing out this single effect to be relevant to therapeutics findings. However, as far as we know, Mangifera indica has one or no translational drugs or products already established in clinical trials or pharmaceutical practice. This is rather a concern in drug discovery and optimization, particularly for Magnifera indica plant which has various medicinal efficacies been ascribed to its properties. It has been investigated already that, Mangiferin a very potent bioactive compound found inside extracts of Magnifera indica , being a polyphenolic and a glucosyl xanthone has strong antioxidant and anti-inflammatory properties. Various effects like antibacterial, antipyretic, anti diarrhoeal, anti allergic, immunomodulation, anti microbial, gastroprotective have also been ascribed to medicinal use of Mangifera indica . Other phytochemistry found in Mangifera indica includes; Saponin, tannins, steroids, flavoniod, alkaloids, cardiac glycosides, reducing sugar and anthraquinone. All these have been seen to be useful in herbal medicine and cosmetics. Thus, this paper focus on the need to encourage the lead optimization and to adequately promote further research that will formulate bioactive compounds in Magnifera indica for the purpose of treating inflammatory diseases, and the need to conduct more clinical trials using Mangifera indica bioactive compounds for variety of conditions in human volunteers.