Selenium dietary intake and survival among CRC patients.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS International Journal for Vitamin and Nutrition Research Pub Date : 2023-12-01 Epub Date: 2022-09-30 DOI:10.1024/0300-9831/a000768
Malgorzata Augustyniak, Aleksander Galas
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引用次数: 2

Abstract

Background: Despite advances in prevention and treatment, colorectal cancer remains the second most common cause of cancer death. To date, little is known about the role of prediagnostic selenium intake in colorectal cancer survival. Objective: The purpose of the study was to verify whether selenium intake in habitual diet before diagnosis is associated with survival in colorectal cancer patients. Study design: This was a prospective observation of patients primarily recruited for a case-control study between 2000 and 2012 in Cracow, Poland. A group of 671 incident cases of colorectal cancer was included. Habitual diet was assessed using a validated 148-item food questionnaire. 338 deaths were identified throughout 2017 by the Polish National Vital Registry. To evaluate the impact of dietary selenium on survival, the multivariable Cox regression model was used. Results: After standardization for several potential confounders (including key determinants, such as radical surgery, chemotherapy, tumor stage, and dietary factors), a decrease in the risk of death from colorectal cancer was observed in the group with higher dietary selenium intake (≥48.8 μg/day, group mean: 63.9 μg/day) compared to the group with lower dietary selenium intake (<48.8 μg/day, mean: 38.5 μg/day) (HR=0.73; 95% CI: 0.54-0.98) (the median was used for categorization). Conclusion: Our study suggests selenium as an additional dietary factor which may be associated with survival among colorectal cancer patients referred to surgery. Due to the observational nature of the study, the results should be taken with caution. These preliminary findings, however, provide the basis for well-structured clinical trials.

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硒的膳食摄入量与 CRC 患者的存活率。
背景:尽管在预防和治疗方面取得了进步,但结直肠癌仍然是第二大常见的癌症死因。迄今为止,人们对诊断前硒摄入量对结直肠癌存活率的作用知之甚少。研究目的本研究旨在验证大肠癌患者在确诊前的习惯饮食中硒的摄入量是否与生存率有关。研究设计:这是一项前瞻性观察,对象主要是 2000 年至 2012 年期间在波兰克拉科夫招募的病例对照研究患者。研究纳入了 671 例结肠直肠癌病例。使用经过验证的 148 项食物问卷对习惯饮食进行了评估。波兰国家生命登记处在 2017 年全年确定了 338 例死亡病例。为评估膳食硒对生存率的影响,采用了多变量 Cox 回归模型。结果显示在对几种潜在混杂因素(包括根治性手术、化疗、肿瘤分期和饮食因素等关键决定因素)进行标准化处理后,与膳食硒摄入量较低的群体相比,膳食硒摄入量较高的群体(≥48.8 μg/天,群体平均值:63.9 μg/天)的结直肠癌死亡风险有所降低(结论:膳食硒摄入量较高的群体的结直肠癌死亡风险有所降低,而膳食硒摄入量较低的群体的结直肠癌死亡风险有所降低:我们的研究表明,硒是可能与接受手术治疗的结直肠癌患者的生存率有关的额外饮食因素。由于研究具有观察性质,因此应谨慎对待研究结果。不过,这些初步研究结果为结构合理的临床试验提供了依据。
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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