Antisense Editorial Office to Move

A. Krieg
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Abstract

FOR THE LAST DECADE, the editorial office of the Antisense & Nucleic Acid Drug Development journal has been at the University of Iowa. During this time, the antisense field has undergone dramatic development, capped by the approval of the first antisense drug by the Food and Drug Administration and by the progressive increase in the number of antisense oligonucleotides used in human clinical trials. Some of these other antisense oligonucleotides are currently in phase III human clinical trials and seem likely to be approved by the FDA within the next few years. In addition to antisense oligonucleotides, therapeutic oligonucleotides that work through nonantisense mechanisms have also entered the clinic. Immune stimulatory oligonucleotides with CpG motifs are currently being evaluated in more than ten human clinical trials as immune activators for treatment or prevention of infectious diseases, cancer, and allergies. In order to promote the further clinical development of these CpG oligos, I will be taking a leave of absence from the University of Iowa and moving to Boston to join the Coley Pharmaceutical Group which is seeking to commercialize CpG technology. I will continue to run the editorial office of Antisense & Nucleic Acid Drug Development from the Coley Pharmaceutical Group headquarters. For our readers, there should be no apparent change in the functioning of the journal. However, we ask our authors and reviewers to note the new address of the editorial office and to make sure that correspondence and manuscripts are sent to this new address, effective immediately. It is: 93 Worcester Street, Suite 101, Wellesley, MA 02481. The phone number is: (781) 431-6400. The fax number is: (781) 4316403. The e-mail address is: akrieg@coleypharma.com We trust that the next decade of Antisense & Nucleic Acid Drug Development will be even more exciting than the last one!
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反义编辑部搬迁
在过去的十年里,《反义与核酸药物开发》杂志的编辑部一直设在爱荷华大学。在此期间,反义领域经历了戏剧性的发展,美国食品和药物管理局批准了第一种反义药物,以及用于人体临床试验的反义寡核苷酸数量的逐步增加。其他一些反义寡核苷酸目前正处于人体临床试验的第三阶段,似乎有可能在未来几年内获得FDA的批准。除了反义寡核苷酸外,通过非反义机制起作用的治疗性寡核苷酸也已进入临床。具有CpG基序的免疫刺激寡核苷酸目前在十多个人体临床试验中被评估为治疗或预防传染病、癌症和过敏的免疫激活剂。为了促进这些CpG低聚物的进一步临床开发,我将离开爱荷华大学,前往波士顿加入Coley制药集团,该集团正在寻求CpG技术的商业化。我将继续在科利制药总部管理《反义与核酸药物开发》编辑部。对于我们的读者来说,杂志的功能应该没有明显的变化。然而,我们要求我们的作者和审稿人注意编辑部的新地址,并确保信件和手稿发送到这个新地址,立即生效。地址:马萨诸塞州韦尔斯利市伍斯特街93号101室,邮编02481。电话号码是:(781)431-6400。传真号码:(781)4316403。我们相信,反义与核酸药物开发的下一个十年将比上一个十年更加精彩!
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Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Delivery of antisense oligonucleotide to the cornea by iontophoresis. Rapid identification of antisense mRNA-expressing clones using strand-specific RT-PCR. Analysis of a mitochondrial apoptotic pathway using Bid-targeted ribozymes in human MCF7 cells in the absence of a caspase-3-dependent pathway. HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.
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