Progress of Tumor-Derived Exosomes in Head and Neck Squamous Cell Carcinoma

Wenmin Zhao, F. Yu
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Abstract

: Exosomes are extracellular vesicles 40 to 160 nm in diameter that mainly mediate information transmission and substance exchange between cells, and increasing evidence suggests that exosomes are involved in the development of tumors and have great potential in cancer diagnosis and treatment. Squamous cell carcinoma of head and neck is one of the common malignant tumors in the whole body. Although various treatments continue to develop, the 5-year survival rate remains only 50%, which may be related to its characteristics such as easy lymphatic metastasis, chemotherapy resistance and poor radiotherapy sensitivity. Researchers are paying more and more attention to TDE
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头颈部鳞状细胞癌肿瘤源性外泌体研究进展
外泌体是直径40 ~ 160nm的细胞外囊泡,主要介导细胞间的信息传递和物质交换,越来越多的证据表明外泌体参与肿瘤的发生发展,在癌症的诊断和治疗中具有很大的潜力。头颈部鳞状细胞癌是全身常见的恶性肿瘤之一。虽然各种治疗方法不断发展,但5年生存率仍仅为50%,这可能与其易淋巴转移、耐化疗、放疗敏感性差等特点有关。研究人员对TDE的研究越来越重视
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