Pub Date : 2024-07-04DOI: 10.11648/j.crj.20241203.11
B. Samuel, Amos Dangana, Taofeeq Oduola, Chinedu Onwuchekwa, Yinka Oyeniyi, M. Dansura, V. Gagari, Mercy Mobi, Ezeama Chika, A. Omoare, Muhammad Usman, Agwu Ojenya, N. Gyang, Chinwe N. Ugwu, Idris Abdullahi
Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria. This case-control study involved 100 subjects (60 cancer patients and 40 healthy control subjects). Their blood samples were collected to measure the levels of G6PD and oxidative stress markers (malondialdehyde, total plasma peroxide, total antioxidant potential, and oxidative stress indices). Twenty-four (40.0%) of the cancer patients were G6PD deficient. Of this, 13 (54.2%) were females G6PD. Of the G6PD deficient cancer patients, 11(45.8%) were male, conversely, 16 (44.4%) of the cancer subjects who had normal G6PD were males. Of the cancer patients, 26.7%; 13.3%, 11.7 % and 10% had prostate, breast cancer, chronic lymphocytic leukemia (CLL), and hepatocellular carcinoma (HCC), respectively were the most frequent. There was no significant association between G6PD deficiency and cancer (X2=0.025, p=0.804). Among G6PD deficiency cancer patients, the oxidative stress markers were significantly (p<0.05) higher compared to the control group. These findings showed that relatively more of the cancer patients had normal G6PD status even in increased cellular oxidative stress which could be due to host genetic factors. This suggests the need for further experiments on molecular characterization of mechanisms responsible for the findings.
{"title":"Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers Among Cancer Patients in Jos, Nigeria","authors":"B. Samuel, Amos Dangana, Taofeeq Oduola, Chinedu Onwuchekwa, Yinka Oyeniyi, M. Dansura, V. Gagari, Mercy Mobi, Ezeama Chika, A. Omoare, Muhammad Usman, Agwu Ojenya, N. Gyang, Chinwe N. Ugwu, Idris Abdullahi","doi":"10.11648/j.crj.20241203.11","DOIUrl":"https://doi.org/10.11648/j.crj.20241203.11","url":null,"abstract":"Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria. This case-control study involved 100 subjects (60 cancer patients and 40 healthy control subjects). Their blood samples were collected to measure the levels of G6PD and oxidative stress markers (malondialdehyde, total plasma peroxide, total antioxidant potential, and oxidative stress indices). Twenty-four (40.0%) of the cancer patients were G6PD deficient. Of this, 13 (54.2%) were females G6PD. Of the G6PD deficient cancer patients, 11(45.8%) were male, conversely, 16 (44.4%) of the cancer subjects who had normal G6PD were males. Of the cancer patients, 26.7%; 13.3%, 11.7 % and 10% had prostate, breast cancer, chronic lymphocytic leukemia (CLL), and hepatocellular carcinoma (HCC), respectively were the most frequent. There was no significant association between G6PD deficiency and cancer (<I>X<sup>2</sup></I>=0.025, <i>p</i>=0.804). Among G6PD deficiency cancer patients, the oxidative stress markers were significantly (<i>p<</i>0.05) higher compared to the control group. These findings showed that relatively more of the cancer patients had normal G6PD status even in increased cellular oxidative stress which could be due to host genetic factors. This suggests the need for further experiments on molecular characterization of mechanisms responsible for the findings.\u0000","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.11648/j.crj.20241201.12
Yiming Liu, Dongping Ye
{"title":"Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone","authors":"Yiming Liu, Dongping Ye","doi":"10.11648/j.crj.20241201.12","DOIUrl":"https://doi.org/10.11648/j.crj.20241201.12","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"101 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139615892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-11DOI: 10.11648/j.crj.20241201.11
Xiaolong Liu, Changhe Cheng
{"title":"Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma","authors":"Xiaolong Liu, Changhe Cheng","doi":"10.11648/j.crj.20241201.11","DOIUrl":"https://doi.org/10.11648/j.crj.20241201.11","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"29 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139533431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognosis of Breast Cancer in Relation with Estrogen-Progesterone and HER-2 Receptor Status","authors":"Shamsun Nahar, N. Mollah, Md Saidul Haque, Md Jamal Uddin, Sarwar Alam, Faruk Ahammad, Khursheda Akhter, Shejuti Sharmin, Afsana Sharmin Anika, N. Akhter","doi":"10.11648/j.crj.20231104.15","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.15","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139002338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.11648/j.crj.20231104.14
Samy M Attallah, Youssef Mohammed Mosaad, Mona Mohamed Taalab, Noha Nasser Eisa, Amal Mahmoud Hammad, Iman Mohammed Fawzy, Nada Youssef, Ashraf Antar Elghzaly
{"title":"<I>GATA3</I> rs3824662<i>, IKZF1</i> (rs4132601& rs11978267), and <I>ARID5B</I> (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia","authors":"Samy M Attallah, Youssef Mohammed Mosaad, Mona Mohamed Taalab, Noha Nasser Eisa, Amal Mahmoud Hammad, Iman Mohammed Fawzy, Nada Youssef, Ashraf Antar Elghzaly","doi":"10.11648/j.crj.20231104.14","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.14","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"264 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.11648/j.crj.20231104.13
Deng Juan
{"title":"A Study of Symptom Experience of Hepatocellular Carcinoma Patients After Hepatic Arterial Infusion Chemotherapy Surgery","authors":"Deng Juan","doi":"10.11648/j.crj.20231104.13","DOIUrl":"https://doi.org/10.11648/j.crj.20231104.13","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"258 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.11648/j.crj.20231103.13
Philip de Melo, M. Davtyan
: Breast cancer is one of the most common cancers diagnosed in the United States. Breast cancer can occur in both men and women. The number of deaths associated with this disease is steadily declining, largely due to factors such as earlier detection and a new personalized approach to treatment. In this article, we offer a highly accurate and reliable classification approach based on feature engineering and an improved support vector machine (SVM) classifier. We examine a dataset with 30 features and use in-depth data analytics and visualization to pinpoint the top nine features that have a significant impact on classification accuracy. The SVM classification outperformed other classifiers, including kernel extensions, with a high accuracy of 99.12%. The study stresses the value of machine learning in medical diagnosis, notably in the early detection of breast cancer
{"title":"High Accuracy Classification of Populations with Breast Cancer: SVM Approach","authors":"Philip de Melo, M. Davtyan","doi":"10.11648/j.crj.20231103.13","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.13","url":null,"abstract":": Breast cancer is one of the most common cancers diagnosed in the United States. Breast cancer can occur in both men and women. The number of deaths associated with this disease is steadily declining, largely due to factors such as earlier detection and a new personalized approach to treatment. In this article, we offer a highly accurate and reliable classification approach based on feature engineering and an improved support vector machine (SVM) classifier. We examine a dataset with 30 features and use in-depth data analytics and visualization to pinpoint the top nine features that have a significant impact on classification accuracy. The SVM classification outperformed other classifiers, including kernel extensions, with a high accuracy of 99.12%. The study stresses the value of machine learning in medical diagnosis, notably in the early detection of breast cancer","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89552072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-17DOI: 10.11648/j.crj.20231103.12
Conde Ansoumane, F. Naby, Soumaoro Labilé Togba, Kondano Saa Yawo, F. Houssein, T. Aboubacar
{"title":"Gastric Cancers: Surgical Management and Prognostic Factors in the General Surgery Department of the National Ignace Deen Hospital, Conakry (Guinea)","authors":"Conde Ansoumane, F. Naby, Soumaoro Labilé Togba, Kondano Saa Yawo, F. Houssein, T. Aboubacar","doi":"10.11648/j.crj.20231103.12","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.12","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77633272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.11648/j.crj.20231103.11
Hailong Zhu, Xuyou Zhu, Xiaoli Li, R. Cui
{"title":"Lentivirus-Mediated Overexpression of miR-218-5p Inhibits Metastasis by Targeting CDH2 in Colorectal Cancer","authors":"Hailong Zhu, Xuyou Zhu, Xiaoli Li, R. Cui","doi":"10.11648/j.crj.20231103.11","DOIUrl":"https://doi.org/10.11648/j.crj.20231103.11","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82547595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge, Sexual Behaviors on Human Papillomavirus Infections and Associated Factors: Survey Among Female Adolescents and Adults in the Republic of Congo","authors":"Roch Bredin Bissala Nkounkou, Estelle Géraldine Essangui Same, Loic Pradel Kojom Foko, Parfait Christy Nganga, Paola Candyse Tsimba Lemba, Austin Mas Ngoulou Ntsiba, Luc Magloire Anicet Boumba, Fabien Roch Niama, Carole Else Eboumbou Moukoko","doi":"10.11648/j.crj.20231102.14","DOIUrl":"https://doi.org/10.11648/j.crj.20231102.14","url":null,"abstract":"","PeriodicalId":9422,"journal":{"name":"Cancer Research Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85528334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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