Yuedong Yang, Yongguo Zhou, W.-L Hou, Yongguang Zhao, Y. Ren
{"title":"Preparation and Anticoagulant Activity of Sulfated 6-Carboxychitosan","authors":"Yuedong Yang, Yongguo Zhou, W.-L Hou, Yongguang Zhao, Y. Ren","doi":"10.1109/ICBBE.2008.241","DOIUrl":null,"url":null,"abstract":"6-Carboxychitosan (6-CC), prepared by selectively oxidization of chitosan powder with NO2 gas in glacial acetic acid, was sulfated with chlorosulfoni acid in formamide to give sulfated 6-carboxylchitosan (S6CC). In S6CC, -SO3H groups were primarily grafted on -NH2, next on secondary -OH, and thirdly on -CH2OH positions. Sodium salt of S6CC (Na-S6CC) was more similar with heparin sodium than sulfated chitosan in both structure and anticoagulation activity.","PeriodicalId":6399,"journal":{"name":"2008 2nd International Conference on Bioinformatics and Biomedical Engineering","volume":"1 1","pages":"982-985"},"PeriodicalIF":0.0000,"publicationDate":"2008-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2008 2nd International Conference on Bioinformatics and Biomedical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICBBE.2008.241","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
6-Carboxychitosan (6-CC), prepared by selectively oxidization of chitosan powder with NO2 gas in glacial acetic acid, was sulfated with chlorosulfoni acid in formamide to give sulfated 6-carboxylchitosan (S6CC). In S6CC, -SO3H groups were primarily grafted on -NH2, next on secondary -OH, and thirdly on -CH2OH positions. Sodium salt of S6CC (Na-S6CC) was more similar with heparin sodium than sulfated chitosan in both structure and anticoagulation activity.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
