Phage banks as potential tools to rapidly and cost-effectively manage antimicrobial resistance in the developing world

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2022-04-01 DOI:10.1016/j.coviro.2022.101208
Tobi Nagel , Lillian Musila , Milkah Muthoni , Mikeljon Nikolich , Jesca L Nakavuma , Martha RJ Clokie
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引用次数: 12

Abstract

Lower and middle-income countries seldom develop vaccines and therapeutics for their own populations and are dependent on supplies from industrialized countries, which are often hampered by financial or supply chain limitations. This has resulted in major delays in delivery with significant loss of life, as seen with the coronavirus pandemic. Since the vast majority of deaths from the antimicrobial resistance crisis are expected to occur in developing countries, there is an urgent need for in-country production of antibacterial therapies such as phages. Nationally controlled phage banks might provide such a solution since locally developed phage therapies tailored to endemic bacterial strains could offer cost-effective antibiotic alternatives.

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噬菌体库作为发展中国家快速和经济有效地管理抗菌素耐药性的潜在工具
低收入和中等收入国家很少为本国人口开发疫苗和治疗方法,并依赖工业化国家的供应,而这些供应往往受到财政或供应链限制的阻碍。正如冠状病毒大流行所示,这导致了严重的交付延误和重大的生命损失。由于抗菌素耐药性危机造成的绝大多数死亡预计将发生在发展中国家,因此迫切需要在国内生产噬菌体等抗菌疗法。国家控制的噬菌体库可能提供这样一种解决方案,因为当地开发的针对地方性细菌菌株的噬菌体疗法可能提供具有成本效益的抗生素替代品。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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