Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2022-09-01 DOI:10.1016/j.scog.2022.100249

Philip D. Harvey , Marta Bosia , Roberto Cavallaro , Oliver D. Howes , René S. Kahn , Stefan Leucht , Daniel R. Müller , Rafael Penadés , Antonio Vita

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引用次数: 22

Abstract

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.

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精神分裂症的认知功能障碍:一份关于当前艺术状态的专家组论文

精神分裂症患者的认知障碍是临床和功能恢复的主要障碍之一。这篇专家组论文汇集了精神分裂症治疗领域的专家，讨论认知障碍领域的科学进展，以最有效的方式解决认知障碍及其后果。我们报告了认知缺陷的发病和病程，将其与精神分裂症患者大脑功能和结构的改变联系起来，并讨论了它们在预测高危人群向精神病过渡中的作用。然后，我们讨论了功能和社会认知方面的评估工具，研究了主观测量的作用，并探讨了测量功能结果的新方法，包括基于技术的方法。最后，我们简要回顾了认知缺陷的治疗方案，重点介绍了认知修复方案，强调了它们对大脑活动的影响，并总结了将认知修复与其他方法相结合的个性化综合干预的潜在益处。

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