Murad I.H Helaleh , T Korenaga , Eyad S.M Abu-Nameh , Rasheed M.A.Q Jamhour
{"title":"Assay of paracetamol by oxidation with peroxydisulphate","authors":"Murad I.H Helaleh , T Korenaga , Eyad S.M Abu-Nameh , Rasheed M.A.Q Jamhour","doi":"10.1016/S0031-6865(98)00032-6","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>A new simple and accurate kinetic method for the analysis of paracetamol in pure form and formulations is described. The kinetics parameters have been applied successfully in determining paracetamol when it reacts with </span>persulfate in alkaline medium. The spectrophotometric measurements have been recorded at 315 nm and found to be valid over the concentration range of 5–30 ppm. The molar absorptivity is equal to 6.55×10</span><sup>3</sup> l mol<sup>−1</sup> cm<sup>−1</sup>. The analysis of paracetamol content in mixture of different substances has been carried out without prior separation. The precision and accuracy of the method and the effect of foreign substances have been studied and the results obtained were compared with reference method.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 5","pages":"Pages 255-260"},"PeriodicalIF":0.0000,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00032-6","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000326","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
A new simple and accurate kinetic method for the analysis of paracetamol in pure form and formulations is described. The kinetics parameters have been applied successfully in determining paracetamol when it reacts with persulfate in alkaline medium. The spectrophotometric measurements have been recorded at 315 nm and found to be valid over the concentration range of 5–30 ppm. The molar absorptivity is equal to 6.55×103 l mol−1 cm−1. The analysis of paracetamol content in mixture of different substances has been carried out without prior separation. The precision and accuracy of the method and the effect of foreign substances have been studied and the results obtained were compared with reference method.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
