Detecting homocysteine in cardiovascular disease using aptasensors: A review

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Sensors and Actuators Reports Pub Date : 2023-10-26 DOI:10.1016/j.snr.2023.100178

Sara Ranjbari , Tannaz Jamialahmadi , Reza Arefinia , Amirhossein Sahebkar

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Abstract

Homocysteine (Hcy) is a non-protein sulfuric amino acid that is produced as a by-product of methionine transmethylation. Increased levels of Hcy in human serum result in hyperhomocysteinemia, which is an indicator for coagulation problems and cardiovascular diseases (CVDs). Therefore, serum Hcy has been suggested as a biomarker to determine redox dysfunction in humans. However, it is necessary to use a reliable method to determine the amount of Hcy in biological fluids and its significance in health and disease. Several studies have used aptamer-based electrochemical sensors (aptasensors) to detect Hcy. The focus of these studies was on speeding up detection and creating novel detection techniques. Apatasensing technology has the potential to improve the diagnosis and treatment of cardiovascular problems. The goal of this review is to provide a general overview of the various Hcy aptasensors in relation to their linear range, detection abilities, and potential medical uses.

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应用适体传感器检测心血管疾病同型半胱氨酸:综述

同型半胱氨酸(Hcy)是一种非蛋白质的硫酸氨基酸，是蛋氨酸转甲基化的副产物。人血清中Hcy水平升高导致高同型半胱氨酸血症，这是凝血问题和心血管疾病(cvd)的一个指标。因此，血清Hcy已被认为是确定人类氧化还原功能障碍的生物标志物。然而，有必要使用一种可靠的方法来确定生物体液中Hcy的含量及其在健康和疾病中的意义。一些研究使用了基于适配体的电化学传感器(aptassensors)来检测Hcy。这些研究的重点是加快检测速度和创造新的检测技术。apatassensing技术有潜力改善心血管疾病的诊断和治疗。本综述的目的是对各种Hcy配体传感器的线性范围、检测能力和潜在的医疗用途进行概述。

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来源期刊

Sensors and Actuators Reports Multiple-

CiteScore

9.60

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications. For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.