A comparative study of the scabicidal activities of formulations of essential oil of Lippia multiflora Moldenke and benzyl benzoate emulsion BP

International Journal of Aromatherapy Pub Date : 2005-01-01 DOI:10.1016/j.ijat.2005.03.005

F.A. Oladimeji , L.O. Orafidiya , T.A.B. Ogunniyi , T.A. Adewunmi , O. Onayemi

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引用次数: 8

Abstract

The scabicidal activities of two topical emulsion formulations (Lippia oil emulsions A and B), each containing 20% w/w essential oil of Lippia multiflora (Lippia oil), were compared with that of benzyl benzoate emulsion BP using randomized, double blind and group parallel studies. The percentage cure obtained for Lippia oil emulsion A were 50%, 80% and 80% on application for 3, 5 and 7 days, respectively, compared with 30%, 60% and 70% obtained for benzyl benzoate emulsion BP for the same treatment periods. There was no significant difference between the percentages of scabietic subjects cured with the two formulations (A and B) of Lippia oil (P > 0.05). Six adverse effects were reported for the Lippia oil emulsions, while 10 adverse effects were reported for benzyl benzoate emulsion BP. Since the Lippia oil emulsions were more effective and better tolerated than the benzyl benzoate emulsion, they were considered as additional formulations for the treatment of scabies.

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何首乌精油与苯甲酸苄酯乳剂BP的杀癣活性比较研究

采用随机、双盲和组平行研究的方法，比较了两种外用乳剂(Lippia oil乳剂A和B)的杀疥疮活性，每种乳剂含有20% w/w的Lippia精油(Lippia oil)。Lippia油乳剂A在施用3、5和7 d时的固化率分别为50%、80%和80%，而苯甲酯乳剂BP在相同的处理时间内的固化率分别为30%、60%和70%。两种配方(A、B)对疥疮患者的治愈率无显著差异(P >0.05)。利皮亚油乳剂有6例不良反应，苯甲酸苄酯乳剂BP有10例不良反应。由于Lippia油乳剂比苯甲酸苄酯乳剂更有效，耐受性更好，因此它们被认为是治疗疥疮的额外配方。

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