Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

IF 1.7 Q2 Medicine Advances in integrative medicine Pub Date : 2022-09-01 DOI:10.1016/j.aimed.2022.04.001
Fatemeh Sadat Hasheminasab , Maryam Azimi , Mahmood Khodadoost , Bahram Chouban , Nezhat Shakeri , Saeedeh Ghasemi , Azam Farokhi , Roshanak Mokaberinajad
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引用次数: 2

Abstract

Background

With the pandemic of coronavirus disease 2019 (COVID-19), and the growing attention of people around the world to the use of traditional and complementary medicines to control of the disease, evaluating the effectiveness of these treatments has received special attention.

Aim

This study aimed to assess the clinical efficacy of a barley-based (Hordeum vulgare) remedy combined with conventional medicine in comparison to the conventional therapy in confirmed COVID-19 patients.

Materials and methods

Seventy COVID-19 patients were randomly divided into barley-based remedy plus conventional medicine (barley-based remedy group) and conventional therapy (control group). Both groups were treated for 5 days. The outcomes were oxygen saturation, main symptoms (fever, respiratory rate, cough, and fatigue), and laboratory data (lymphocytic count, and CRP); they were measured for 6 days.

Results

In comparison to the control group, the oxygen saturation level in the barley-based remedy group significantly increased, from the second day of the intervention (P < 0.05). The herbal remedy significantly improved fatigue from the third day (P < 0.05). Meanwhile, the severity and frequency of cough between the groups were not significantly different. The herbal remedy had no significant effect on the CRP and the lymphocytic count of every time points of measurement. The average of respiratory rate and temperature of patients were in the normal range in both groups during the intervention.

Conclusion

Barley-based remedy could significantly enhance the blood oxygen saturation and reduce fatigue. However, it needs to be confirmed by large sample size trials.

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以大麦为基础的波斯药物配方对2019冠状病毒病(COVID-19)住院患者的疗效:一项开放标签随机对照试验
随着2019年冠状病毒病(COVID-19)的大流行,以及世界各地人们越来越关注使用传统和补充药物来控制疾病,评估这些治疗方法的有效性受到了特别关注。目的评价以大麦为基础的中药联合常规药物治疗新冠肺炎确诊患者的临床疗效。材料与方法将70例COVID-19患者随机分为大麦方加常规药物组(大麦方组)和常规治疗组(对照组)。两组均治疗5 d。结果包括血氧饱和度、主要症状(发热、呼吸频率、咳嗽和疲劳)和实验室数据(淋巴细胞计数和CRP);随访6天。结果与对照组相比,大麦基疗法组患者血氧饱和度从干预第2天起显著升高(P <0.05)。该药从第3天起显著改善疲劳(P <0.05)。同时,两组患者咳嗽的严重程度和频率无显著差异。中药对CRP及各时间点淋巴细胞计数无明显影响。干预期间两组患者呼吸频率和体温均在正常范围内。结论大麦汤能明显提高血氧饱和度,减轻疲劳。然而,这需要通过大样本量的试验来证实。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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