Advances in integrative medicine最新文献

Effect of DU meridian long snake moxibustion on intestinal flora of people with yang deficiency 杜氏经络长蛇灸对阳虚体质者肠道菌群的影响

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.07.002

Background

The changes of intestinal flora are closely related to the occurrence and development of many diseases. Long snake moxibustion has the functions of strengthening the body resistance, eliminating pathogenic factors and balancing yin and yang, and has been widely used in clinic. This study aimed to explore the effect of long snake moxibustion on intestinal flora in people with yang deficiency constitution.

Methods

The 60 subjects with yang deficiency constitution recruited in a tertiary A-level-integrated traditional Chinese medicine hospital were randomly divided into Du meridian group and non-Du meridian group between May 1, 2021, and July 31, 2021, which were treated once a week for 12 consecutive times. The scores of symptoms of yang deficiency were recorded before and after treatment, fresh stool samples were collected, and the distribution of intestinalflora was detected by 16 S rDNA sequencing technology.

Results

Compared with before treatment, the scores of symptoms of yang deficiency in both groups had a distinct decrease after treatment (P<0.05), and the effect of Du meridian group was better than that of non-Du meridian group. After treatment, the Du meridian group was superior to the non-Du meridian treatment group in the diversity of intestinal flora, the relative abundance of phylum and genus, and the dominant intestinal flora.

Conclusions

Long snake moxibustion on Du meridian can improve the diversity of intestinal flora, promote the balance between beneficial bacteria and harmful bacteria, enhance the integrity of intestinal epithelial barrier and regulate intestinal immunity, thus improving Yang deficiency constitution.

背景肠道菌群的变化与多种疾病的发生、发展密切相关。长蛇灸具有增强机体抵抗力、消除致病因素、平衡阴阳等作用，已广泛应用于临床。本研究旨在探讨长蛇灸对阳虚体质人群肠道菌群的影响。方法将2021年5月1日至2021年7月31日期间在某三级甲等综合中医院招募的60名阳虚体质受试者随机分为督脉组和非督脉组，每周治疗1次，连续治疗12次。结果与治疗前相比，治疗后两组患者的阳虚症状评分均有明显下降（P<0.05），且本组效果优于非本组。结论长蛇灸督脉可改善肠道菌群的多样性，促进有益菌与有害菌的平衡，增强肠道上皮屏障的完整性，调节肠道免疫功能，从而改善阳虚体质。

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引用次数: 0

A hot-water extract of Sargassum hemiphyllum as the sole treatment for allergic contact dermatitis – A case report 马尾藻热水提取物作为过敏性接触性皮炎的唯一治疗方法--病例报告

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.06.003

Introduction

Corticosteroids remain the mainstay of treatment for contact dermatitis, but there is a practical need to provide alternatives to patients concerned about the safety of these drugs. Sargassum hemiphyllum, a very common brown macroalga found on coasts of the Greater China, has been shown to be an abundant source of anti-inflammatory substances.

Case description

Presented below is the use of a crude, S. hemiphyllum hot-water extract (SHHWE) as the sole treatment in a patient with widespread allergic contact dermatitis. A 47-year-old female beautician presented with widespread allergic contact dermatitis on upper abdomen. She refused corticosteroid therapy and preferred conservative, moisturizer-based treatments. The SHHWE was used as the sole moisturizer and the patient recovered uneventfully within 6 weeks without requiring any medications.

Conclusions

This case, for the first time, illustrates the feasibility of using a SHHWE as the main treatment for allergic contact dermatitis. Such extracts may be considered in these patients who opt for non-corticosteroid, symptomatic treatments under medical supervision.

导言皮质类固醇仍然是治疗接触性皮炎的主要药物，但由于患者担心这些药物的安全性，因此有必要为他们提供替代药物。马尾藻（Sargassum hemiphyllum）是大中华地区沿海一种非常常见的褐色大型藻类，已被证明是抗炎物质的丰富来源。病例描述以下是使用粗制马尾藻热水提取物（SHHWE）作为广泛过敏性接触性皮炎患者的唯一治疗方法。一位 47 岁的女性美容师上腹部出现大面积过敏性接触性皮炎。她拒绝接受皮质类固醇治疗，更倾向于保守的保湿治疗。将 SHHWE 用作唯一的保湿剂，患者在 6 周内顺利康复，无需服用任何药物。对于在医生指导下选择非皮质类固醇对症治疗的患者，可以考虑使用这种提取物。

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引用次数: 0

The efficacy of evening primrose seed oil supplements on ART outcomes: A triple-blinded randomized placebo-controlled clinical trial 月见草籽油补充剂对 ART 结果的疗效：三重盲法随机安慰剂对照临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.08.004

Background

Evening primrose oil (EPO) has been extensively documented for its potential benefits in various medical conditions, including gestational diabetes, inflammatory diseases, cyclic breast pain, cancer, premenstrual syndrome, menopausal syndrome, and female reproductive disorders.

Objectives

The aim of this study was to investigate the impact of evening primrose oil (EPO) supplementation on the outcomes of assisted reproductive technology (ART).

Methods

A randomized, triple-blinded, placebo-controlled clinical trial was conducted. A total of 84 infertile women who were candidates for intracytoplasmic sperm injection (ICSI) were randomly assigned to either the EPO supplementation group or the placebo (p) group with a 1:1 ratio. The EPO capsule was given from day 1–2 of the ART cycle at a dosage of 1000 mg every eight hours for two weeks. Finally, the ART outcomes parameters as well as the treatment side effects were evaluated.

Results

The results illustrated no statistically significant disparities between the groups in terms of the number of oocytes retrieved, ovarian sensitivity index (OSI), rate of fertilization, and number and quality of embryos (p>0.05). However, a notably enhanced incidence of pregnancy and implantation rates in the EPO group was observed when compared to the P group (42.9 % vs. 17.4 % and 23±30.5 % vs. 10.87±26 %, respectively). Moreover, none of the patients experienced side effects from the intervention.

Conclusions

EPO consumption for two weeks could improve ART outcomes by increasing implantation and pregnancy rates without significantly affecting the number of mature oocytes, rate of fertilization, and the quantity and quality of embryos. These findings highlight the significance of a maternal preconception diet.

背景月见草油（EPO）因其对妊娠糖尿病、炎症性疾病、周期性乳房疼痛、癌症、经前综合征、更年期综合征和女性生殖系统疾病等多种疾病的潜在益处而被广泛报道。方法进行了一项随机、三盲、安慰剂对照临床试验。共有 84 名不孕妇女作为卵胞浆内单精子显微注射（ICSI）的候选者，按 1:1 的比例被随机分配到补充 EPO 组或安慰剂（p）组。在抗逆转录病毒疗法周期的第 1-2 天开始服用 EPO 胶囊，剂量为每 8 小时服用 1000 毫克，连续服用两周。最后，对 ART 的结果参数以及治疗的副作用进行了评估。结果表明，各组在取卵数量、卵巢敏感性指数（OSI）、受精率以及胚胎数量和质量方面没有统计学意义上的显著差异（p>0.05）。不过，与 P 组相比，EPO 组的妊娠率和植入率明显提高（分别为 42.9% 对 17.4%，23±30.5% 对 10.87±26%）。结论服用 EPO 两周可提高植入率和妊娠率，从而改善 ART 的结果，而不会显著影响成熟卵母细胞的数量、受精率以及胚胎的数量和质量。这些研究结果突显了孕产妇孕前饮食的重要性。

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引用次数: 0

Osteopathy: A potential ally against anorexia? 整骨疗法：对抗厌食症的潜在盟友？

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.08.002

Introduction

This article addresses the complex relationship between body perception and anorexia through some examples of body psychotherapy frameworks that also integrate osteopathic principles. We aim to correlate these perspectives and propose directions for future research integrating psychiatry and osteopathy.

Methods

We review and discuss various theoretical paradigms, including psychiatric, psychoanalytic, body-psychotherapeutic models. By synthesizing insights from these diverse fields, we underscore the potential benefits of an osteopathic practice that prioritizes psychological considerations.

Results

The interest in transdisciplinary and holistic clinical methodologies has been increasing. We draw parallels between the practices of psychiatrist Wilhelm Reich (1897–1957) and osteopathy founder Andrew Taylor Still (1828–1917) in addressing psychosomatic disorders. In the same time, recent studies substantiate the efficacy of somatic approaches for patients with anorexia.

Discussion

Despite limited empirical evidence supporting osteopathy's role in treating anorexia, several theoretical observations indicate its potential utility. These findings suggest promising avenues for future clinical research combining osteopathy, psychomotricity and psychiatry.

引言本文通过一些身体心理疗法框架的实例，探讨了身体感知与厌食症之间的复杂关系，这些框架也融合了整骨疗法的原则。方法我们回顾并讨论了各种理论范式，包括精神病学、精神分析、身体心理治疗模型。通过综合这些不同领域的见解，我们强调了优先考虑心理因素的整骨疗法的潜在益处。结果人们对跨学科和整体临床方法的兴趣与日俱增。我们将精神病学家威廉-赖希（Wilhelm Reich，1897-1957 年）和整骨疗法创始人安德鲁-泰勒-斯蒂尔（Andrew Taylor Still，1828-1917 年）在治疗心身疾病方面的实践相提并论。同时，最近的研究证实了躯体疗法对厌食症患者的疗效。讨论尽管支持骨病学在治疗厌食症方面作用的经验证据有限，但一些理论观察表明了它的潜在作用。这些发现为今后结合骨病学、精神医学和精神病学开展临床研究提供了广阔的前景。

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引用次数: 0

The reasons for the use of traditional and complementary medicine by cancer patients in Morocco 摩洛哥癌症患者使用传统和补充医学的原因

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.06.001

Purpose

More than a third of cancer patients use traditional and complementary medicines (T&CM) in the Beni Mellal Khenifra region of Morocco. No study has investigated the reasons for this use. Our objective is to explore the main resaons this use.

Methods

Between April and October 2022, 200 cancer patients from the Beni Mellal oncology center participated in a qualitative and descriptive study with semi-structured interviews. We used thematic analysis to identify reasons for use.

Results

156 patients used T&CM (78 %). The majority used natural products, including medicinal plants. The first four reasons given by the patients were the hope of recovery (25.64 %), the reduction of the undesirable effects of conventional treatments (20.51 %), the improvement of the quality of life (physical, psychological, and esthetic) (17.94 %) and following traditions and customs (15.38 %).

Conclusion

The four reasons mentioned can explain the use of T&CM. Given the discrepancies found in other studies, this area of research deserves further investigation across Morocco.

目的在摩洛哥 Beni Mellal Khenifra 地区，超过三分之一的癌症患者使用传统和补充药物（T&CM）。还没有研究调查过使用这种药物的原因。2022 年 4 月至 10 月间，贝尼梅拉尔肿瘤中心的 200 名癌症患者参加了一项半结构式访谈的定性和描述性研究。我们采用主题分析法来确定使用的原因。结果156 名患者使用了 T&CM（78%）。大多数患者使用天然产品，包括药用植物。患者给出的前四个原因分别是希望康复（25.64%）、减少常规治疗的不良反应（20.51%）、提高生活质量（生理、心理和审美）（17.94%）以及遵循传统和习俗（15.38%）。鉴于其他研究中发现的差异，这一研究领域值得在摩洛哥全国范围内开展进一步调查。

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引用次数: 0

The safety and tolerability of Annona muricata leaf product in people living with cancer: Study protocol 癌症患者服用鼠尾草叶产品的安全性和耐受性：研究方案

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.06.004

Objectives

The objective of this study was to design a clinical study protocol to investigate the safety and tolerability of Annona muricata, in people living with advanced malignancy. Anecdotal clinical evidence suggests this herb has potential anti-cancer activity. There are numerous pre-clinical studies detailing Annona muricata’s main bioactive constituents. To date, clinical studies evaluating the efficacy, safety and tolerability are limited.

Design

This phase 1 open label study will involve people living with stage III and IV cancers of any type, who are not undergoing chemotherapeutic treatment.

Methods

The primary outcome is safety and tolerability of an Annona muricata leaf product as measured by participants’ self-reporting of adverse effects experienced and the proportion of participants completing the study. Secondary outcomes include biomarkers of inflammation and immune function, disease status and self-reported quality of life scores. Participants (n = 24) will be allocated to one of two groups for 12 weeks. Participants will commence at different timepoints and be assigned to either 530 mg or 1060 mg of Annona muricata daily. The study has been approved by the Human Research Ethics Committee Bellberry and will be reported in compliance with the SPIRIT statement. This study has been registered with the Australian New Zealand Clinical Trials Register.

Results and conclusions

The results of this study will provide safety and tolerability data for clinicians involved in the care of people living with cancer who choose to use Annona muricata products as an integrative approach to their healthcare. The results of this study will inform further research about the potential role of Annona muricata in cancer.

研究目的：本研究旨在设计一项临床研究方案，以调查晚期恶性肿瘤患者对鼠李子（Annona muricata）的安全性和耐受性。临床轶事证据表明，这种草药具有潜在的抗癌活性。许多临床前研究详细介绍了鼠李子的主要生物活性成分。方法主要研究结果是鼠李子叶产品的安全性和耐受性，通过参与者对不良反应的自我报告和完成研究的参与者比例来衡量。次要结果包括炎症和免疫功能的生物标志物、疾病状况和自我报告的生活质量评分。参与者（n = 24）将被分配到两组中的一组，为期 12 周。参与者将从不同的时间点开始，每天服用530毫克或1060毫克鼠尾草。该研究已获得贝尔贝里人类研究伦理委员会（Human Research Ethics Committee Bellberry）的批准，并将按照SPIRIT声明进行报告。本研究已在澳大利亚-新西兰临床试验注册机构注册。结果与结论本研究的结果将为临床医生提供安全性和耐受性数据，以帮助选择使用鼠李子茴香产品作为综合保健方法的癌症患者。这项研究的结果将为进一步研究鼠李子对癌症的潜在作用提供信息。

{"title":"The safety and tolerability of Annona muricata leaf product in people living with cancer: Study protocol","authors":"","doi":"10.1016/j.aimed.2024.06.004","DOIUrl":"10.1016/j.aimed.2024.06.004","url":null,"abstract":"<div><h3>Objectives</h3><p>The objective of this study was to design a clinical study protocol to investigate the safety and tolerability of <em>Annona muricata</em>, in people living with advanced malignancy. Anecdotal clinical evidence suggests this herb has potential anti-cancer activity. There are numerous pre-clinical studies detailing <em>Annona muricata’</em>s main bioactive constituents. To date, clinical studies evaluating the efficacy, safety and tolerability are limited.</p></div><div><h3>Design</h3><p>This phase 1 open label study will involve people living with stage III and IV cancers of any type, who are not undergoing chemotherapeutic treatment.</p></div><div><h3>Methods</h3><p>The primary outcome is safety and tolerability of an <em>Annona muricata</em> leaf product as measured by participants’ self-reporting of adverse effects experienced and the proportion of participants completing the study. Secondary outcomes include biomarkers of inflammation and immune function, disease status and self-reported quality of life scores. Participants (n = 24) will be allocated to one of two groups for 12 weeks. Participants will commence at different timepoints and be assigned to either 530 mg or 1060 mg of <em>Annona muricata</em> daily<em>.</em> The study has been approved by the Human Research Ethics Committee Bellberry and will be reported in compliance with the SPIRIT statement. This study has been registered with the Australian New Zealand Clinical Trials Register.</p></div><div><h3>Results and conclusions</h3><p>The results of this study will provide safety and tolerability data for clinicians involved in the care of people living with cancer who choose to use <em>Annona muricata</em> products as an integrative approach to their healthcare. The results of this study will inform further research about the potential role of <em>Annona muricata</em> in cancer.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212958824000624/pdfft?md5=587064c0ab6609e83f2cec5f81581411&pid=1-s2.0-S2212958824000624-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteopathy in the Italian healthcare landscape: Perceptions and areas of competence according to healthcare professionals 意大利医疗保健领域的整骨疗法：医疗保健专业人员的看法和能力领域

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.07.003

Objectives

The healthcare context aims to create a multidisciplinary culture that places the patient at the center of the care process, and osteopathy plays a significant and evolving role. This study aimed to examine the perceptions of healthcare professionals regarding the role of osteopathy in the Italian hospital healthcare setting.

Design

This cross-sectional observational study involved the collection of 327 questionnaires. Subsequently, data from 302 questionnaires were selected and evaluated in accordance with the inclusion and exclusion criteria.

Methods

The survey was conducted through a questionnaire specifically developed for the study and administered using Google Forms. The questionnaire included specific domains for the analysis of demographic data and data related to the perception of the osteopathic discipline. Electronic distribution of the survey was achieved through a snowball sampling approach, requiring participants' informed consent.

Results

Regarding the age distribution of the respondents, the majority fell within the 25–34 age bracket, constituting 37 % of the sample. When asked about their profession, the vast majority identified as nurses (80 %). It emerged that among the 203 respondents who confirmed seeking osteopathic consultation, the primary motivations were related to musculoskeletal disorders.

Discussion

The evolving healthcare landscape emphasizes the importance of multidisciplinary collaboration. Respondents show a strong inclination toward incorporating osteopathy into interdisciplinary care models. As healthcare shifts towards holistic, patient-centered models, including osteopathy in multidisciplinary teams could enhance therapeutic options and improve patient care quality.

目标医疗保健领域旨在创建一种多学科文化，将患者置于医疗保健过程的中心，而骨科疗法在其中扮演着重要且不断发展的角色。本研究旨在考察医护人员对骨科疗法在意大利医院医疗环境中的作用的看法。设计本横断面观察性研究共收集了 327 份问卷。随后，根据纳入和排除标准对 302 份问卷中的数据进行了筛选和评估。方法调查是通过专门为本研究开发的问卷进行的，并使用谷歌表格进行管理。调查问卷包括用于分析人口统计学数据和骨科学科认知相关数据的特定领域。在征得参与者知情同意的前提下，通过滚雪球式抽样方法以电子方式发放调查问卷。结果关于受访者的年龄分布，大多数受访者属于 25-34 岁年龄段，占样本的 37%。当被问及职业时，绝大多数人认为自己是护士（80%）。在确认寻求骨科咨询的 203 名受访者中，主要动机与肌肉骨骼疾病有关。受访者强烈倾向于将整骨疗法纳入跨学科医疗模式。随着医疗保健向全面、以患者为中心的模式转变，将骨病学纳入多学科团队可增强治疗方案并提高患者护理质量。

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引用次数: 0

Integrative medicine healthcare, research and education 中西医结合医疗保健、研究和教育

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.08.011

引用次数: 0

Efficacy and safety of wet cupping in the management of Gout: An open labeled, randomized standard control study 湿拔罐治疗痛风的有效性和安全性：开放标签、随机标准对照研究

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.07.001

Background

The most prevalent form of inflammatory arthritis is Gouty arthritis. Wet cupping, a traditional regimental therapy of Greco-Arab and Chinese medicine, has been proven an effective and safe alternative treatment for multiple disorders especially in musculoskeletal ailments.

Aims and objectives

To study the efficacy and safety of wet cupping in Gouty arthritis.

Methods

In an open-labeled, randomized and standard controlled trial 60 patients of gout fulfilling the inclusion criteria were randomly allocated in test group (n=30) receiving wet cupping and the control group (n=30) receiving allopurinol for a period of 60 days. Patients were assessed at every 15th day for subjective parameters/symptoms, whereas for objective parameters (serum uric acid, inflammatory markers) assessment was done at 0th day and on 61st day of the study protocol. The data was analyzed statistically using student t-test to obtain the results.

Results

Both the test and control groups showed a significant improvement in subjective parameters (p<0.001). Serum uric acid gets significantly improved after the treatment (p<0.001) in both the groups, however among inflammatory markers, better improvement in ESR was seen in test group (p< 0.05) than control group (p=0.37) but there was no considerable improvement in CRP either in test or control group. All the safety parameters (LFT, KFT) were found to remain undisturbed after completion of study protocol.

Conclusion

Wet cupping has a considerable impact in improving the symptoms of gout and serum uric acid levels. It is much safer and could prove a better alternative for gout management.

背景痛风性关节炎是炎症性关节炎中最常见的一种。方法在一项开放标签、随机和标准对照试验中，60 名符合纳入标准的痛风患者被随机分配到试验组（30 人）和对照组（30 人），试验组接受湿拔罐治疗，对照组接受别嘌呤醇治疗，为期 60 天。每隔 15 天对患者的主观参数/症状进行评估，而客观参数（血清尿酸、炎症指标）评估则在研究方案的第 0 天和第 61 天进行。结果试验组和对照组的主观指标均有显著改善（p<0.001）。两组治疗后血清尿酸均有明显改善（p<0.001），但在炎症指标中，试验组的血沉（p<0.05）比对照组有更好的改善（p=0.37），但试验组和对照组的 CRP 均无明显改善。所有安全参数（低密度脂蛋白胆固醇、高密度脂蛋白胆固醇）在研究方案完成后均保持不变。湿拔罐在改善痛风症状和血清尿酸水平方面效果显著，而且更加安全，可以证明是治疗痛风的一种更好的替代方法。

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引用次数: 0

The effect of flaxseed on lipid profile in healthy individuals: A systematic review and dose-response meta-analysis of clinical trials 亚麻籽对健康人血脂状况的影响：临床试验的系统回顾和剂量反应荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.aimed.2024.08.006

Introduction

Findings on the effects of flaxseed on the lipid profile in healthy individuals are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard.

Methods

After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of flaxseed on the lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), Apolipoprotein -A (apo-A) and Apolipoprotein -B (apo-B)] in healthy individuals.

Results

Altogether, 16 studies with a total sample size of 1000 were included in the analysis. Combining 17 effect sizes from 16 RCTs, we found a significant lowering effect of flaxseed on serum levels of TG (weighted mean difference (WMD): < 0.001, 95 % CI: −0.05–0.05 mmol/L; p = 0.996), TC (WMD: 0.23 mmol/l; 95 % CI: −0.34 to −0.13; p &l; 0.001), LDL-C (WMD): −0.15 mmol/l; 95 % CI: −0.26 to −0.05; p = 0.003), HDL-C (WMD): −0.05 mmol/l; 95 % CI: −0.09 to −0.02; p = 0.001), apo-A (WMD): 0.16 g/l; 95 % CI: −0.26–0.58; p= 0.465) and apo-B (WMD): −0.06 g/l; 95 % CI: −0.15–0.02; p = 0.131).

Conclusion

The present study demonstrates the beneficial effects of flaxseed on TC, HDL-C, and LDL-C in healthy people.

导言亚麻籽对健康人血脂状况的影响研究结果相互矛盾。目前的综合系统综述和荟萃分析旨在总结这方面的现有证据。方法在对在线数据库进行系统检索后，我们纳入了研究亚麻籽对健康人血脂状况[总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白-A（apo-A）和载脂蛋白-B（apo-B）]影响的随机对照试验（RCT）。结果共有 16 项研究纳入分析，样本量共计 1000 个。综合 16 项研究的 17 个效应大小，我们发现亚麻籽对血清中的 TG（加权平均差 (WMD)：< 0.001，95 % CI：-0.05-0.05 mmol/L；p = 0.996）、TC（WMD：0.23 mmol/l；95 % CI：-0.34 至 -0.13；p &l; 0.001）、LDL-C（WMD）有显著的降低作用：低密度脂蛋白胆固醇（WMD）：-0.15 毫摩尔/升；95 % CI：-0.26 至-0.05；p = 0.003），高密度脂蛋白胆固醇（WMD）：-0.05 毫摩尔/升；95 % CI：-0.26 至-0.05；p = 0.003-0.05毫摩尔/升；95 % CI：-0.09至-0.02；p = 0.001），载脂蛋白-A（WMD）：0.16克/升；95 % CI：-0.26至0.58；p= 0.465）和载脂蛋白-B（WMD）：-0.06克/升；95 % CI：-0.26至-0.05；p= 0.003）：-结论本研究表明，亚麻籽对健康人的总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇有益。

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引用次数: 0