Endothelial function in patients with COPD: an updated systematic review of studies using flow-mediated dilatation.

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2023-01-01 DOI:10.1080/17476348.2023.2176845
Anouk W Vaes, Patrick De Boever, Frits M E Franssen, Nicole H M K Uszko-Lencer, Lowie E G W Vanfleteren, Martijn A Spruit
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引用次数: 1

Abstract

Introduction: Cardiovascular disease is a significant cause of morbidity and mortality in COPD. Endothelial dysfunction is suggested to be involved in cardiovascular disease pathogenesis, and multiple studies report endothelial dysfunction in COPD. This article summarized the current knowledge on endothelial function in COPD patients.

Areas covered: Databases were screened until November 2022 for studies using ultrasound-based flow-mediated dilation in patients with stable COPD. Pooled effect sizes were calculated using random effects model. Meta-regression analyses assessed the effects of demographic and clinical variables.

Expert opinion: 34 studies were identified (1365 COPD patients; 617 controls). Pooled analysis demonstrated an impaired endothelial-dependent (-2.33%; 95%CI -3.30/-1.35; p < 0.001) and endothelial-independent dilation (-3.11%; 95%CI -5.14/-1.08; p = 0.003) in COPD patients when compared to non-COPD controls. Meta-regression identified that higher age, worse severity of airflow obstruction, and current smoking were significantly associated with impaired endothelial function. Studies evaluating the effects of pharmacological and non-pharmacological interventions on endothelial function in COPD patients demonstrated conflicting results.

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COPD患者的内皮功能:对血流介导扩张研究的最新系统综述
前言:心血管疾病是慢性阻塞性肺病发病和死亡的重要原因。内皮功能障碍被认为参与心血管疾病的发病机制,多项研究报道了COPD的内皮功能障碍。本文综述了目前COPD患者内皮功能的相关知识。涵盖领域:数据库筛选至2022年11月,用于在稳定期COPD患者中使用基于超声的血流介导扩张的研究。采用随机效应模型计算合并效应量。meta回归分析评估了人口统计学和临床变量的影响。专家意见:共纳入34项研究(1365例COPD患者;617控制)。合并分析显示内皮依赖性受损(-2.33%;95%可信区间-3.30/-1.35;p
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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
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