When the right (Drug) should be left: Prenatal drug exposure and heterotaxy syndrome

Nicole R. van Veenendaal, Cynthia D.J. Kusters, Roelof-Jan Oostra, Jorieke E.H. Bergman, Jan-Maarten Cobben
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引用次数: 5

Abstract

Background

Recent studies reported an association between prenatal propylthiouracil exposure and birth defects, including abnormal arrangement across the left–right body axis, suggesting an association with heterotaxy syndrome.

Methods

This case–control and case-finding study used data from 1981 to 2013 from the EUROCAT birth defect registry in the Northern Netherlands. First, we explored prenatal exposures in heterotaxy syndrome (cases) and Down syndrome (controls). Second, we describe the specific birth defects in offspring of mothers using propylthiouracil (PTU) prenatally.

RESULTS

A total of 66 cases with heterotaxy syndrome (incidence 12.1 per 100,000 pregnancies) and 783 controls with Down syndrome (143.3 per 100,000 pregnancies) were studied. No differences in intoxication use during pregnancy were found between cases and controls, including smoking (28.0% vs. 22.7%; p = 0.40), alcohol (14.0% vs. 26.9%; p = 0.052), and recreational drugs (0 vs. 0.3%; p = 1.00). We found an association between heterotaxy syndrome and prenatal drug exposure to follitropin-alfa (5.6% vs. 1.1%; p = 0.04), and drugs used in nicotine dependence (3.7% vs. 0.2%; p = 0.02). Five mothers used PTU during pregnancy and gave birth to a child with trisomy 18, renal abnormalities, or hypospadias and cardiac defects.

Conclusion

This study identified follitropin-alfa and drugs used in nicotine dependence as possible teratogens of heterotaxy syndrome. Our data suggest the possibility that there is an increased risk of birth defects (including renal, urological, and cardiac abnormalities) in children born among mothers taking PTU prenatally, but not for heterotaxy syndrome. Birth Defects Research (Part A) 106:573–579, 2016. © 2016 Wiley Periodicals, Inc.

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右(药)时应左:产前药物暴露和异位综合征
最近的研究报道了产前丙硫尿嘧啶暴露与出生缺陷之间的关系,包括在左右体轴上的异常排列,这表明与异位综合征有关。方法本病例对照和病例发现研究使用了1981年至2013年荷兰北部EUROCAT出生缺陷登记处的数据。首先,我们探讨了异位综合征(病例)和唐氏综合征(对照组)的产前暴露。其次,我们描述了母亲在产前使用丙基硫脲嘧啶(PTU)的后代的特定出生缺陷。结果共纳入66例异位综合征(发病率12.1 / 10万例)和783例唐氏综合征(发病率143.3 / 10万例)对照。在怀孕期间,病例和对照组之间的中毒使用没有差异,包括吸烟(28.0%对22.7%;P = 0.40)、酒精(14.0% vs. 26.9%;P = 0.052)和娱乐性药物(0 vs. 0.3%;P = 1.00)。我们发现异位综合征与产前药物暴露于卵磷脂- α之间存在关联(5.6% vs 1.1%;P = 0.04),以及尼古丁依赖的药物使用(3.7% vs. 0.2%;P = 0.02)。5位母亲在怀孕期间使用PTU,生下了一个患有18三体、肾脏异常或尿道下裂和心脏缺陷的孩子。结论卵泡素- α和尼古丁依赖药物可能是异位综合征的致畸源。我们的数据表明,产前服用PTU的母亲所生的孩子有可能增加出生缺陷(包括肾脏、泌尿系统和心脏异常)的风险,但不存在异位综合征。出生缺陷研究(A辑)(06):573 - 579,2016。©2016 Wiley期刊公司
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来源期刊
Birth defects research. Part A, Clinical and molecular teratology
Birth defects research. Part A, Clinical and molecular teratology 医药科学, 胎儿发育与产前诊断, 生殖系统/围生医学/新生儿
CiteScore
1.86
自引率
0.00%
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0
审稿时长
3 months
期刊最新文献
Issue Information Cover Image Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685–695 (10.1002/bdra.23517) Acardiac twin pregnancies part III: Model simulations. Diprosopus: Systematic review and report of two cases.
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