Clinical effects of combined Lactobacillus paracasei and kestose on canine atopic dermatitis.

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Polish journal of veterinary sciences Pub Date : 2023-03-01 DOI:10.24425/pjvs.2023.145014
K Kawano, K Iyori, N Kondo, S Yamakawa, T Fujii, K Funasaka, Y Hirooka, T Tochio
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引用次数: 1

Abstract

Probiotics and prebiotics are viable bacteria with beneficial effects on the host and components that selectively act on the beneficial commensal bacteria, respectively. The combined use of probiotics and prebiotics is termed synbiotics. Probiotic intake improves dysbiosis in the intestinal microbiota and can positively affect canine atopic dermatitis (CAD). However, clinical studies on improvements in CAD using synbiotics remain limited. In this study, 15 dogs with CAD who received prednisolone, a synthetic glucocorticoid (GC) used in the treatment of CAD, for more than 90 days were continuously treated with Lactobacillus paracasei M-1 from fermented food as a probiotic, and trisaccharide kestose as a prebiotic, for 90 days to determine their synbiotic effects on CAD. The CAD symptoms were evaluated using the canine atopic dermatitis lesion index (CADLI) and pruritus visual analog scores (PVAS) at 30, 60 and 90 days after synbiotic administration. The total prednisolone use for 90 days pre- and post-administration was also evaluated. Synbiotic administration significantly reduced the CADLI (pre: median, 28.0 [22.0-32.0]; 30 days: median, 20.0 [20.0-28.0]; 60 days: median, 20.0 [10.0-21.0]; 90 days: median, 12.0 [10.0-19.0]) and PVAS (pre: median, 6.0 [5.0-7.0]; 30 days: median, 3.0 [3.0-3.5]; 60 days: median, 3.0 [3.0-3.5]; 90 days: median, 2.0 [2.0-3.5]) scores, and reduced the total prednisone use over 90 days (pre: 112.0 [25-450] mg; post: 80.0 [18.-300.0] mg; p⟨0.001) in the 15 dogs. Thus, the synbiotic activity of L. paracasei M-1 and trisaccharide kestose can improve CAD.

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副干酪乳杆菌与酮症糖联合治疗犬特应性皮炎的临床疗效。
益生菌和益生元分别是对宿主有益的活菌和选择性作用于有益共生菌的组分。益生菌和益生元的联合使用被称为合成益生菌。益生菌的摄入改善了肠道微生物群的生态失调,并对犬特应性皮炎(CAD)有积极的影响。然而,使用合生剂改善CAD的临床研究仍然有限。在本研究中,15只患有CAD的狗接受了用于治疗CAD的合成糖皮质激素(GC)强的松龙(prednisolone)治疗超过90天,连续使用发酵食品中的副干酪乳杆菌M-1作为益生菌,三糖酮糖作为益生元,持续90天,以确定它们对CAD的合成作用。采用犬特应性皮炎病变指数(CADLI)和瘙痒视觉模拟评分(PVAS)在给药后30、60和90天对CAD症状进行评估。还评估了给药前后90天的泼尼松龙总使用量。给药显著降低CADLI(前:中位数,28.0 [22.0-32.0];30天:中位数,20.0 [20.0-28.0];60天:中位数,20.0 [10.0-21.0];90天:中位数,12.0[10.0-19.0])和PVAS(前期:中位数,6.0 [5.0-7.0];30天:中位数,3.0 [3.0-3.5];60天:中位数,3.0 [3.0-3.5];90天:中位数,2.0[2.0-3.5])评分,90天内泼尼松总使用量减少(前:112.0 [25-450]mg;后:80.0 [18.0 -300.0]mg;P = 0.001)。因此,副干酪乳杆菌M-1与三糖酮糖的合成活性可以改善CAD。
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来源期刊
Polish journal of veterinary sciences
Polish journal of veterinary sciences 农林科学-兽医学
CiteScore
1.40
自引率
0.00%
发文量
60
审稿时长
12-24 weeks
期刊介绍: Polish Journal of Veterinary Sciences accepts short communications, original papers and review articles from the field of, widely understood, veterinary sciences - basic, clinical, environmental, animal-origin food hygiene, feed hygiene, etc.
期刊最新文献
149328 143550 139988 143549 A method for the infectivity discrimination of enveloped DNA viruses using palladium compounds pre-treatment followed by real-time PCR.
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