Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI:10.1016/j.semcdb.2022.05.016
Brendon J. Gurd , Eveline Soares Menezes , Benjamin B. Arhen , Hashim Islam
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引用次数: 3

Abstract

The purpose of this review is to explore and discuss the impacts of augmented training volume, intensity, and duration on the phosphorylation/activation of key signaling protein – AMPK, CaMKII and PGC-1α - involved in the initiation of mitochondrial biogenesis. Specifically, we explore the impacts of augmented exercise protocols on AMP/ADP and Ca2+ signaling and changes in post exercise PGC − 1α gene expression. Although AMP/ADP concentrations appear to increase with increasing intensity and during extended durations of higher intensity exercise AMPK activation results are varied with some results supporting and intensity/duration effect and others not. Similarly, CaMKII activation and signaling results following exercise of different intensities and durations are inconsistent. The PGC-1α literature is equally inconsistent with only some studies demonstrating an effect of intensity on post exercise mRNA expression. We present a novel meta-analysis that suggests that the inconsistency in the PGC-1α literature may be due to sample size and statistical power limitations owing to the effect of intensity on PGC-1α expression being small. There is little data available regarding the impact of exercise duration on PGC-1α expression. We highlight the need for future well designed, adequately statistically powered, studies to clarify our understanding of the effects of volume, intensity, and duration on the induction of mitochondrial biogenesis by exercise.

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改变运动量、强度和持续时间对AMPK和CaMKII的激活以及PGC-1α mRNA的增加的影响
本综述的目的是探索和讨论增加训练量、强度和持续时间对参与线粒体生物发生起始的关键信号蛋白AMPK、CaMKII和PGC-1α磷酸化/激活的影响。具体而言,我们探讨了增强运动方案对AMP/ADP和Ca2+信号传导的影响,以及运动后PGC−1α基因表达的变化。尽管AMP/ADP浓度似乎随着强度的增加和高强度运动的延长持续时间而增加,但AMPK激活结果各不相同,一些结果支持强度/持续时间效应,而另一些结果则不支持。类似地,不同强度和持续时间的运动后CaMKII的激活和信号传导结果是不一致的。PGC-1α文献同样与仅一些研究表明强度对运动后mRNA表达的影响不一致。我们提出了一项新的荟萃分析,表明PGC-1α文献中的不一致性可能是由于样本量和统计能力的限制,因为强度对PGC-1 a表达的影响很小。关于运动时间对PGC-1α表达的影响,目前几乎没有可用的数据。我们强调,未来需要进行精心设计、充分统计的研究,以澄清我们对运动诱导线粒体生物发生的体积、强度和持续时间影响的理解。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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