Bruno L. Marques , Giovana Figueiredo Maciel , Marcello R. Brito Júnior , Lucas D. Dias , Sérgio Scalzo , Anderson K. Santos , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Rodrigo R. Resende
{"title":"Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis","authors":"Bruno L. Marques , Giovana Figueiredo Maciel , Marcello R. Brito Júnior , Lucas D. Dias , Sérgio Scalzo , Anderson K. Santos , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Rodrigo R. Resende","doi":"10.1016/j.semcdb.2022.09.014","DOIUrl":null,"url":null,"abstract":"<div><p>The world population’s life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling<span><span> of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, </span>microRNAs<span>, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy.</span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"144 ","pages":"Pages 11-19"},"PeriodicalIF":6.2000,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in cell & developmental biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1084952122002762","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 3
Abstract
The world population’s life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, microRNAs, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy.
期刊介绍：
Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications.
The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
