Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2021.100049
Bianca Costa , Luana Barbosa Corrêa , Patrícia MachadoRodrigues e Silva , Yago Amigo Pinho Jannini de Sá , Fernanda Verdini Guimarães , Luciana Magalhães Rebelo Alencar , Rafael Loureiro Simões , Edward Helal-Neto , Eduardo Ricci-Junior , Maria das Graças Muller de Oliveira Henriques , Elaine Cruz Rosas , Ralph Santos-Oliveira
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Abstract

Inflammation is a phenomenon responsible for the perturbation of homeostasis in several levels, with many sources, such as infection, injury, and exposure to contaminants. The necessity of new products that are effective in treating inflammation processes as can selectively imaging an inflammation site is a global issue. In this study, we have evaluated the applicability of Fucoidan as a therapeutic and imaging agent. We have assessed the Fucoidan in two inflammation models for therapeutic purposes: arthritis and lungs (LPS). In the case of use as an imaging agent, we evaluated the radiolabeled Fucoidan with 99mTc in inflamed lungs (LPS). The results demonstrated that Fucoidan has a therapeutic anti-inflammatory effect, especially in the lung model (LPS). Additionally, the imaging application demonstrated that radiolabeled Fucoidan (99mTc-Fucoidan) has an important chemoattraction for inflammation sites with very high bioaccumulation, which permits to think in an imaging application.

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使用纯岩藻糖聚糖和放射性标记岩藻糖聚糖(99mtc -岩藻糖聚糖)作为炎症诊断和治疗的新药物
炎症是一种在多个层面上扰乱体内平衡的现象,其来源有许多,如感染、损伤和暴露于污染物。需要有效治疗炎症过程的新产品,因为可以选择性地成像炎症部位是一个全球性的问题。在这项研究中,我们评估了岩藻糖聚糖作为治疗和显像剂的适用性。我们已经评估了岩藻聚糖在两种炎症模型中的治疗目的:关节炎和肺(LPS)。在使用显像剂的情况下,我们评估了99mTc在炎症肺(LPS)中的放射性标记岩藻糖聚糖。结果表明岩藻多糖具有治疗性抗炎作用,特别是对肺模型(LPS)。此外,成像应用表明,放射性标记的岩藻多糖(99mtc -岩藻多糖)对具有很高生物积累的炎症部位具有重要的化学吸引力,这允许在成像应用中进行思考。
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