Stuttering as a spectrum disorder: A hypothesis

Shahriar SheikhBahaei , Marissa Millwater , Gerald A. Maguire
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Abstract

Childhood-onset fluency disorder, commonly referred to as stuttering, affects over 70 million adults worldwide. While stuttering predominantly initiates during childhood and is more prevalent in males, it presents consistent symptoms during conversational speech. Despite these common clinical manifestations, evidence suggests that stuttering, may arise from different etiologies, emphasizing the need for personalized therapy approaches. Current research models often regard the stuttering population as a singular, homogenous group, potentially overlooking the inherent heterogeneity. This perspective consolidates both historical and recent observations to emphasize that stuttering is a heterogeneous condition with diverse causes. As such, it is crucial that both therapeutic research and clinical practices consider the potential for varied etiologies leading to stuttering. Recognizing stuttering as a spectrum disorder embraces its inherent variability, allowing for a more nuanced categorization of individuals based on the underlying causes. This perspective aligns with the principles of precision medicine, advocating for tailored treatments for distinct subgroups of people who stutter, ultimately leading to personalized therapeutic approaches.

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口吃是一种谱系障碍:一种假设
儿童期出现的流利性障碍,通常被称为口吃,影响着全球7000多万成年人。虽然口吃主要是在儿童时期开始的,在男性中更为普遍,但它在会话语言中表现出一致的症状。尽管有这些常见的临床表现,证据表明口吃可能由不同的病因引起,强调需要个性化的治疗方法。目前的研究模式往往把口吃人群视为一个单一的、同质的群体,潜在地忽视了内在的异质性。这一观点结合了历史上和最近的观察结果,强调口吃是一种具有多种原因的异质性疾病。因此,治疗研究和临床实践都要考虑到导致口吃的各种病因的可能性,这一点至关重要。承认口吃是一种谱系障碍,包含了它固有的可变性,允许基于潜在原因对个体进行更细致的分类。这一观点与精准医学的原则相一致,主张针对不同的口吃人群进行量身定制的治疗,最终导致个性化的治疗方法。
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