A collaborative integrative and Ayurvedic approach to cirrhosis in the setting of autoantibody negative autoimmune hepatitis: a case report

IF 1.7 Q2 Medicine Advances in integrative medicine Pub Date : 2022-05-01 DOI:10.1016/j.aimed.2021.10.002
George Schatz , Erica Kumala , Amita Nathwani
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Abstract

Autoimmune hepatitis (AIH) is a chronic and progressive inflammatory process of the liver, with standard treatments including prednisone, azathioprine, and ultimately liver transplant. While there are many integrative and Ayurvedic treatment options that have been shown to be helpful for other liver diseases, there are no studies that have been performed to evaluate these therapies particularly in AIH with cirrhosis. We detail the case of a 55-year-old female with cirrhosis in the setting of AIH placed on a liver transplant list after being treated with conventional therapies. She was started on various nutritional supplements and Ayurvedic treatments which resulted in a significant decrease in her Model for End-Stage Liver Disease score, which was sustained at 7 months. This is the first case report to our knowledge detailing an integrative approach to cirrhosis in the setting of AIH showing such an improvement in liver function. This paper outlines a novel approach to Autoimmune hepatitis with cirrhosis that utilizes a collaboration between Conventional, Integrative and Ayurvedic practitioners. While the basic science supports the efficacy of the individual treatments utilized in this case, there have been no published case reports outlining the safety and efficacy of these treatments when combined in a clinical setting of cirrhosis due to Autoimmune hepatitis. Thus, we set out to detail the first such case report to our knowledge of an integrative approach to cirrhosis in the setting of AIH showing such an improvement in liver function.

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协同整合和阿育吠陀方法肝硬化在自身抗体阴性自身免疫性肝炎设置:一个病例报告
自身免疫性肝炎(AIH)是肝脏慢性进行性炎症过程,标准治疗包括强的松、硫唑嘌呤,最终肝移植。虽然有许多综合和阿育吠陀治疗方案已被证明对其他肝脏疾病有帮助,但还没有研究对这些治疗方法进行评估,特别是对AIH合并肝硬化的治疗。我们详细的情况下,55岁的女性肝硬化设置AIH放置在肝移植名单后,接受传统疗法治疗。她开始服用各种营养补充剂和阿育吠陀治疗,这导致她的终末期肝病模型评分显著下降,持续了7个月。据我们所知,这是第一个详细介绍AIH肝硬化综合治疗方法的病例报告,显示了肝功能的改善。本文概述了一种新的方法来自身免疫性肝炎肝硬化,利用传统,综合和阿育吠陀医生之间的合作。虽然基础科学支持本病例中使用的单个治疗方法的有效性,但尚未发表的病例报告概述了这些治疗方法在自身免疫性肝炎肝硬化临床环境中联合使用的安全性和有效性。因此,我们着手详细介绍我们所知的第一个这样的病例报告,即在AIH背景下采用综合方法治疗肝硬化,显示肝功能的改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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