Nucleic acids and collagen can attenuate ovariectomy-induced degeneration of fibers in the abdominal aortic wall of female rat

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-10-02 DOI:10.1016/j.phanu.2023.100360
Mayo Higashihara , Hirona Kugo , Tomomi Nakamura , Tomoko Sumi , Daisuke Shimizu , Keisuke Kiriyama , Mica Fujita , Keita Sutoh , Tatsuya Moriyama , Nobuhiro Zaima
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Abstract

Background

Women are more resistant to the development of cardiovascular diseases compared with men. However, the vascular integrity of elderly women gradually declines, and their incidence is comparable to that of men. The increased risk of cardiovascular diseases is reportedly associated with menopause. The previous studies which show close relationship between menopause and increased risk of cardiovascular diseases suggest that preventive methods must be established to alleviate this unavoidable menopause-induced vascular degeneration. Functional food factors can be effective for prevention of degeneration of the vascular wall in women. In this study, we evaluated the effects of dietary nucleic acids and collagen on vascular degeneration after ovariectomy (OVX).

Methods

Three-week-old female Sprague-Dawley rats were grouped into 4 groups according to condition: sham-placebo drink, sham-sample drink, OVX-placebo drink, and OVX-sample drink. The sample drink and placebo drink were administered orally until autopsy, respectively. One week later, sham-treatment or OVX was performed, and 7 weeks later, tissues were collected for pathological analysis by staining.

Results

OVX-induced degenerations of vascular fibers, degradation of elastic fiber and denature of collagen, were suppressed in the rats which were administrated nucleic acids and collagen. OVX induced increases of neutrophil elastase and matrix metalloproteinase (MMP) 2 and 9. The increased neutrophil elastase and MMPs were decreased by administration of nucleic acids and collagen. Nucleic acids and collagen suppressed infiltration of macrophages and dysfunction of vascular smooth muscles cells.

Conclusions

These results suggest that nucleic acids and collagen prevent vascular inflammation which results in degeneration of the vascular wall.

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核酸和胶原蛋白能减轻卵巢切除引起的雌性大鼠腹主动脉壁纤维变性
与男性相比,女性对心血管疾病的抵抗力更强。然而,老年女性血管完整性逐渐下降,其发病率与男性相当。据报道,心血管疾病风险的增加与更年期有关。先前的研究表明更年期与心血管疾病风险增加之间的密切关系,建议必须建立预防方法来减轻这种不可避免的更年期引起的血管变性。功能性食物因子可有效预防女性血管壁退化。在这项研究中,我们评估了膳食核酸和胶原蛋白对卵巢切除术后血管变性的影响。方法将3周龄雌性Sprague-Dawley大鼠按条件分为4组:假安慰剂饮料、假样品饮料、ovx -安慰剂饮料和ovx -样品饮料。样品饮料和安慰剂饮料分别被口服,直到尸体解剖。1周后进行假治疗或OVX治疗,7周后收集组织进行染色病理分析。结果sovx诱导的大鼠血管纤维变性、弹性纤维降解和胶原变性均受到抑制。OVX诱导中性粒细胞弹性酶和基质金属蛋白酶(MMP) 2和9升高。核酸和胶原可降低中性粒细胞弹性酶和MMPs的升高。核酸和胶原抑制巨噬细胞浸润和血管平滑肌细胞功能障碍。结论核酸和胶原蛋白具有预防血管炎症导致的血管壁变性的作用。
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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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